Integrin Alpha2b anticorps

N° du produit ABIN2689249

Cité dans 5 publications. Cet anticorps anti-Integrin Alpha2b Monoclonal Rat (Clone MWReg30) (ABIN2689249) détecte spécifiquement Integrin Alpha2b dans FACS, IP, IHC (fro) et CyTox. L’anticorps est réactif avec des échantillons de Souris.

Aperçu rapide pour Integrin Alpha2b anticorps (ABIN2689249)

Antigène: Integrin Alpha2b (CD41)

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Integrin Alpha2b est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Cytotoxicity Test (CyTox)

Clone: MWReg30

Détail du produit anti-Integrin Alpha2b anticorps

Attributs du produit: The MWReg30 antibody reacts with glycoprotein (gp) IIb, also called integrin αIIb chain (CD41), that associates with integrin β3 chain (gpIIIa or CD61) to form the gpIIb/IIIa (CD41/CD61) complex. CD41/CD61 is expressed on platelets, megakaryocytes, and early hematopoietic progenitors. The integrin complex binds to fibrinogen, fibronectin, vitronectin, von Willebrand factor, and thrombospondin. It is important for platelet adhesion and aggregation, and it may play a role in osteolytic tumor metastasis. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature.

BD Pharmingen™ Purified Rat Anti-Mouse CD41 - Purified - Clone MWReg30 - Isotype Rat IgG1, κ - Reactivity Ms - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse Platelets

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-Integrin Alpha2b (ABIN2689249)

Bakewell, Nestor, Prasad, Tomasson, Dowland, Mehrotra, Scarborough, Kanter, Abe, Phillips, Weilbaecher: "Platelet and osteoclast beta3 integrins are critical for bone metastasis." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 24, pp. 14205-10, (2003) (PubMed).

Ferkowicz, Starr, Xie, Li, Johnson, Shelley, Morrison, Yoder: "CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo." dans: Development (Cambridge, England), Vol. 130, Issue 18, pp. 4393-403, (2003) (PubMed).

Nieswandt, Echtenacher, Wachs, Schröder, Gessner, Schmidt, Grau, Männel: "Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice." dans: Blood, Vol. 94, Issue 2, pp. 684-93, (1999) (PubMed).

Kieffer, Phillips: "Platelet membrane glycoproteins: functions in cellular interactions." dans: Annual review of cell biology, Vol. 6, pp. 329-57, (1991) (PubMed).

Phillips, Charo, Scarborough: "GPIIb-IIIa: the responsive integrin." dans: Cell, Vol. 65, Issue 3, pp. 359-62, (1991) (PubMed).

Détails sur Integrin Alpha2b

Antigène: Integrin Alpha2b (CD41)

Autre désignation: CD41

Sujet: Synonyms: Integrin α IIb chain

Pathways: Integrin Complex