CD59 anticorps

N° du produit ABIN2689346

Cet anticorps Souris Monoclonal détecte spécifiquement CD59 dans FACS et IF. Il présente une réactivité envers Humain et a été mentionné dans 3+ publications.

Aperçu rapide pour CD59 anticorps (ABIN2689346)

Antigène: CD59

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD59 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: P282

Détail du produit anti-CD59 anticorps

Marque: BD Pharmingen™

Attributs du produit: Reacts with CD59, a 19 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein, expressed on hematopoietic and non-hematopoietic cells. Because of its role in interaction with complement activated products, CD59 has been termed membrane-attack-complex-inhibitory factor (MACIF), homologus restriction factor (HRF20), membrane inhibitor of reactive lysis (MIRL) and protectin. It inhibits the cytolytic activity of complement by binding to C8 and C9, thereby blocking the assembly of the membrane attack complex. CD59 also participates in spontaneous T-cell/erythrocyte adhesion, interacts with CD2 and plays a role in T-cell activation. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of glycosylphosphatidylinositol (GPI) anchor-defective mutant cell line analyzed on a FACScan Profile of K562 cells expressing glycosylphosphatidylinositol (GPI) anchor protein analyzed on a FACScan

BD Pharmingen™ Purified Mouse Anti-Human CD59 - Purified - Clone p282 (H19) - Isotype Mouse IgG2a, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-CD59 (ABIN2689346)

Davies, Lachmann: "Membrane defence against complement lysis: the structure and biological properties of CD59." dans: Immunologic research, Vol. 12, Issue 3, pp. 258-75, (1994) (PubMed).

Deckert, Kubar, Bernard: "CD58 and CD59 molecules exhibit potentializing effects in T cell adhesion and activation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 3, pp. 672-7, (1992) (PubMed).

Deckert, Kubar, Zoccola, Bernard-Pomier, Angelisova, Horejsi, Bernard: "CD59 molecule: a second ligand for CD2 in T cell adhesion." dans: European journal of immunology, Vol. 22, Issue 11, pp. 2943-7, (1992) (PubMed).

Détails sur CD59

Antigène: CD59

Autre désignation: CD59

Pathways: Système du Complément