FAS anticorps

N° du produit ABIN2689464

Il existe 3+ publications pour ce produit. L’anticorps anti-FAS Monoclonal Souris est utilisé pour la détection de FAS dans des échantillons de Humain. Il a été validé pour FACS, Func et FM.

Aperçu rapide pour FAS anticorps (ABIN2689464)

Antigène: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FAS est non-conjugé

Application: Flow Cytometry (FACS), Functional Studies (Func), Fluorescence Microscopy (FM)

Clone: EOS9-1

Détail du produit anti-FAS anticorps

Attributs du produit: Reacts with a 45 kD type I membrane molecule also known as APO-1, or Fas antigen. CD95 belongs to the tumor necrosis factor receptor (TNF-R) family of proteins and is expressed on various cells, including activated T cells and B cells. The interaction of CD95, Fas antigen, with Fas ligand is one of the many mechanisms that lead to apoptosis or programmed cell death. The interaction of CD95 expressing target cells with Fas ligand on cytotoxic T cells induces an apoptotic signal leading to target cell death. It has been reported that apoptosis is the mechanism used by the immune system in clonal deletion of self-reactive T cells during embryological development. Jurkat cells treated for 6 hours with CD95 (EOS9.1) Jurkat cells treated for 6 hours with mouse IgM isotype control

BD Pharmingen™ Purified Mouse Anti-Human CD95 - Purified - Clone EOS9.1 - Isotype Mouse IgM, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgM kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing no preservative.

Agent conservateur: Without preservative

Conseil sur la manipulation: This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-FAS (ABIN2689464)

Krammer, Dhein, Walczak, Behrmann, Mariani, Matiba, Fath, Daniel, Knipping, Westendorp: "The role of APO-1-mediated apoptosis in the immune system." dans: Immunological reviews, Vol. 142, pp. 175-91, (1995) (PubMed).

Nagata, Golstein: "The Fas death factor." dans: Science (New York, N.Y.), Vol. 267, Issue 5203, pp. 1449-56, (1995) (PubMed).

Rouvier, Luciani, Golstein: "Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity." dans: The Journal of experimental medicine, Vol. 177, Issue 1, pp. 195-200, (1993) (PubMed).

Détails sur FAS

Antigène: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Autre désignation: CD95

Sujet: Synonyms: Fas/APO-1

Pathways: Signalisation p53, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity