ROR1 anticorps

N° du produit ABIN2689893

Détail du produit anti-ROR1 anticorps

Antigène: ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ROR1 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Marque: BD Pharmingen™

Attributs du produit: The 4A5 monoclonal antibody binds to the glycosylated type I membrane protein ROR1 (Receptor-tyrosine-kinase-like Orphan Receptor 1). The ROR1 and ROR2 related proteins are highly conserved evolutionarily and are primarily expressed during embryogenesis. ROR1 is not expressed on normal peripheral blood lymphocytes. ROR1 is similar to tropomyosin receptor kinase (Trk family) neurotropic receptors and shares a cysteine-rich domain with Frizzled receptors for Wnt-family signaling proteins, which are involved in the regulation of embryogenesis and carcinogenesis. Furthermore, there is mounting evidence that aberrant ROR1 expression contributes to human malignancy. ROR1 expression in human embryonal carcinoma cells. Human NCCIT cells (ATCC CRL-2073) were stained with either Purified Mouse IgG2b κ Isotype Control (Cat. No. 555740, dashed line histogram) or Purified Mouse Anti-Human ROR1 (Cat. No. 564464, solid-line histogram) monoclonal antibodies. The second-step reagent was PE Goat Anti-Mouse Ig (Multiple Adsorption) (Cat. No. 550589). The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable NCCIT cells. Flow cytometry was performed using a BD LSRFortessa™ Flow Cytometer System.

BD Pharmingen™ Purified Mouse Anti-Human ROR1 - Purified - Clone 4A5 - Isotype Mouse IgG2b, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human ROR1 cDNA

Clone: 4A5

Isotype: IgG2b kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-ROR1 (ABIN2689893)

Cui, Zhang, Chen, Yu, Widhopf, Fecteau, Rassenti, Kipps: "Targeting ROR1 inhibits epithelial-mesenchymal transition and metastasis." dans: Cancer research, Vol. 73, Issue 12, pp. 3649-60, (2013) (PubMed).

Zhang, Chen, Wang-Rodriguez, Zhang, Cui, Frankel, Wu, Kipps: "The onco-embryonic antigen ROR1 is expressed by a variety of human cancers." dans: The American journal of pathology, Vol. 181, Issue 6, pp. 1903-10, (2012) (PubMed).

Zhang, Chen, Cui, Chuang, Yu, Wang-Rodriguez, Tang, Chen, Basak, Kipps: "ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth." dans: PLoS ONE, Vol. 7, Issue 3, pp. e31127, (2012) (PubMed).

Broome, Rassenti, Wang, Meyer, Kipps: "ROR1 is expressed on hematogones (non-neoplastic human B-lymphocyte precursors) and a minority of precursor-B acute lymphoblastic leukemia." dans: Leukemia research, Vol. 35, Issue 10, pp. 1390-4, (2011) (PubMed).

Fukuda, Chen, Endo, Tang, Lu, Castro, Widhopf, Rassenti, Cantwell, Prussak, Carson, Kipps: "Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 8, pp. 3047-52, (2008) (PubMed).

Détails sur ROR1

Antigène: ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1))

Autre désignation: ROR1 (ROR1 Produits)

Synonymes: anticorps NTRKR1, anticorps dJ537F10.1, anticorps 2810404D04Rik, anticorps Ntrkr1, anticorps mRor1, anticorps RGD1559469, anticorps ROR1, anticorps fi34e02, anticorps si:dkey-209n16.1, anticorps wu:fi34e02, anticorps receptor tyrosine kinase like orphan receptor 1, anticorps receptor tyrosine kinase-like orphan receptor 1, anticorps ROR1, anticorps Ror1, anticorps ror1

Sujet: Synonyms: Neurotrophic tyrosine kinase, receptor-related 1, NTRKR1

Pathways: Signalisation RTK, Signalisation WNT, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha