WNK1 anticorps

N° du produit ABIN271862

Détail du produit anti-WNK1 anticorps

Antigène: WNK1 (WNK Lysine Deficient Protein Kinase 1 (WNK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WNK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of WNK1 protein. (region surrounding Tyr52)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Pureté: > 95 % pure by SDS-PAGE

Information d'application

Indications d'application: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE!

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur WNK1

Antigène: WNK1 (WNK Lysine Deficient Protein Kinase 1 (WNK1))

Autre désignation: WNK1 (WNK1 Produits)

Synonymes: anticorps HSAN2, anticorps HSN2, anticorps KDP, anticorps PRKWNK1, anticorps PSK, anticorps p65, anticorps WNK1, anticorps kdp, anticorps psk, anticorps hsn2, anticorps hsan2, anticorps pha2c, anticorps prkwnk1, anticorps 6430573H23Rik, anticorps EG406236, anticorps Hsn2, anticorps Prkwnk1, anticorps mKIAA0344, anticorps ATWNK1, anticorps T9J14.14, anticorps T9J14_14, anticorps ZIK4, anticorps with no lysine (K) kinase 1, anticorps WNK lysine deficient protein kinase 1, anticorps WNK lysine deficient protein kinase 1 L homeolog, anticorps serine/threonine-protein kinase WNK1, anticorps with no lysine (K) kinase 1, anticorps WNK1, anticorps wnk1.L, anticorps wnk1, anticorps LOC100056745, anticorps Wnk1

Sujet: The protein kinase superfamily contains over a thousand proteins in 57 subfamilies that all share a catalytic core of 250 - 300 amino acids organized in two domains. WNK kinases (With No lysine (K)) are serine-threonine protein kinases that contain a cysteine residue in place of a lysine residue in a family of proteins that traditionally contain a lysine following a short string of hydro-phobic residues. WNK kinases contain a lysine upstream of the traditional position, within a glycine string. This lysine functions as an anchor and orients ATP through interactions with the alpha and beta phosphoryl groups. The catalytic domains of WNK2, WNK3 and WNK4 are 95 % homologous to WNK1. Human WNK1 maps to chromosome 12p13 and encodes a 2382 protein that is primarily expressed in heart, kidney, muscle and distal nephron. Human WNK3 maps to chromosome Xp11.21-p11.23 and encodes a protein that is primarily expressed in brain. Human WNK4 maps to chromosome 17q21-q22 and encodes a 1243 amino acid protein that is expressed in kidney. Aberrant function of WNK kinases and their associated signaling pathways are implicated in hypertension, increased renal salt reabsorption, and impaired K+ and H+ excretion.Synonyms: Erythrocyte 65 kDa protein, KDP, KIAA0344, Kinase deficient protein, PRKWNK1, Protein kinase lysine-deficient 1, Protein kinase with no lysine 1, Serine/threonine-protein kinase WNK1, p65

Poids moléculaire: approx. 230 kDa

ID gène: 65125

NCBI Accession: NP_001171914

UniProt: Q9H4A3