Acetyl-CoA Carboxylase alpha anticorps

N° du produit ABIN271866

Cet anticorps anti-Acetyl-CoA Carboxylase alpha Polyclonal Lapin (ABIN271866) détecte spécifiquement Acetyl-CoA Carboxylase alpha dans WB et IHC (p). L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Acetyl-CoA Carboxylase alpha anticorps (ABIN271866)

Antigène: Acetyl-CoA Carboxylase alpha (ACACA)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Acetyl-CoA Carboxylase alpha est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Acetyl-CoA Carboxylase alpha anticorps

Specificité: This antibody detects endogenous levels of Acetyl-CoA Carboxylase protein. (region surrounding His74)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: ELISA: 1/5000-1/10000. Western blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Acetyl-CoA Carboxylase alpha

Antigène: Acetyl-CoA Carboxylase alpha (ACACA)

Autre désignation: Acetyl-CoA Carboxylase 1

Sujet: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the ratelimiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACC-alpha (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACC-beta (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACC-alpha is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted Serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the short-term regulatory mechanism of the enzyme. The gene encoding ACC-alpha, which maps to human chromosome 17, encodes the 265 kDa alpha form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACC-beta is homologous to that of ACC-alpha except for an additional peptide of about 150 amino acids at the N-terminus.Synonyms: ACAC, ACACA, ACC1, ACCA

Poids moléculaire: approx. 265 kDa

ID gène: 31

NCBI Accession: NP_942131

UniProt: Q13085

Pathways: AMPK Signaling, Ribonucleoside Biosynthetic Process, L'effet Warburg