PLA2G4B anticorps

N° du produit ABIN271921

Cet anticorps Lapin Polyclonal détecte spécifiquement PLA2G4B dans WB, IF et IHC (p). Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PLA2G4B anticorps (ABIN271921)

Antigène: PLA2G4B (Phospholipase A2, Group IVB (Cytosolic) (PLA2G4B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLA2G4B est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-PLA2G4B anticorps

Specificité: This antibody detects endogenous levels of c-PLA2 protein. (region surrounding asn499)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: ELISA: (1/10000approx. 1/20000). Western Blot (1/500approx. 1/1000). Immunohistochemistry (1/50approx. 1/200). Immunofluorescence (1/50approx. 1/200)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur PLA2G4B

Antigène: PLA2G4B (Phospholipase A2, Group IVB (Cytosolic) (PLA2G4B))

Autre désignation: PLA2G4B

Sujet: Phospholipase A2s (PLA2s) constitute a family of esterases that hydrolyze the sn-2-acyl ester bond in glycerophospholipid molecules. These enzymes are generally calcium-dependent and have been found both intra- and extracellularly. By hydrolyzing the sn-2 bond in glycerophospholipids, PLA2s release fatty acids. One such fatty acid, arachidonic acid, generates the substrates for the initiation of the arachidonic acid cascade that produces various eicosanoids (i.e. prostaglandins, leukotrienes and thromboxanes), many of which are potent mediators of inflammation. PLA2s include both the relatively low molecular weight type I and type II enzymes and the form known as cytoplasmic PLA2 (cPLA2). cPLA2 is present in the cytosol of various cells and tissues including platelets, macrophages and monoblasts, and preferentially hydrolyzes the sn-2 position of phospholipid molecules, releasing free arachidonate.Synonyms: Cytosolic phospholipase A2 beta, Phospholipase A2 group IVB, cPLA2-beta, phospholipase A2 beta

Poids moléculaire: approx. 100 kDa

ID gène: 100137049

NCBI Accession: NP_001108105

UniProt: P0C869

Pathways: ER-Nucleus Signaling, VEGF Signaling