GALE anticorps

N° du produit ABIN2721595

L’anticorps anti-GALE Monoclonal Souris est utilisé pour la détection de GALE dans des échantillons de Humain, Rat, Chien et Singe. Il a été validé pour WB et IHC.

Aperçu rapide pour GALE anticorps (ABIN2721595)

Antigène: GALE (UDP-Galactose-4-Epimerase (GALE))

Reactivité: Humain, Rat, Chien, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GALE est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 1C4

Détail du produit anti-GALE anticorps

Attributs du produit: Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 1

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogène: Full length human recombinant protein of human GALE (NP_000394) produced in HEK293T cell.

Isotype: IgG1

Information d'application

Indications d'application: WB 1:500~2000, IHC 1:150,

Commentaires:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur GALE

Antigène: GALE (UDP-Galactose-4-Epimerase (GALE))

Autre désignation: GALE

Sujet: This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.

Poids moléculaire: 38.1 kDa

ID gène: 2582

NCBI Accession: NM_000403

HGNC: 2582

Pathways: Response to Water Deprivation, Cellular Glucan Metabolic Process