TINF2 anticorps

N° du produit ABIN272251

Cet anticorps Lapin Polyclonal détecte spécifiquement TINF2 dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour TINF2 anticorps (ABIN272251)

Antigène: TINF2 (TIN2) (TERF1 Interacting Nuclear Factor 2 (TIN2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TINF2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TINF2 anticorps

Specificité: This antibody detects endogenous levels of TIN2 protein. (region surrounding Val94)

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Pureté: > 95 % pure by SDS-PAGE

Information d'application

Indications d'application: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE!

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur TINF2

Antigène: TINF2 (TIN2) (TERF1 Interacting Nuclear Factor 2 (TIN2))

Autre désignation: TINF2 / TIN2

Sujet: Telomeres are DNA-protein structures that protect the ends of linear chromosomes and help maintain genomic stability and cell phenotype. Mammalian telomeric proteins consist of TRF1 (telomeric repeat binding factor), TRF2, tankyrase, and TIN2, which have no recognized orthologs in the budding yeast, Saccharomyces cerevisiae, and RAP1, which is an ortholog to the yeast telomeric protein scRap1. Like scRap1, mammalian RAP1 regulates telomere elongation. RAP1 interacts with two proteins, Rif1 and Rif2, which contribute to telomere length homeostasis. Unlike scRap1, which binds telomeric DNA directly, RAP1 is recruited to telomeres by TRF2. The functional and structural similarities of scRap1 to mammalian RAP1 suggest that the budding yeast preserved RAP1 at telomeres, but lost the TRF component. The telomeric protein TRF1 requires TIN2 to control telomere length in human cells.Synonyms: TERF1-interacting nuclear factor 2, TRF1-interacting nuclear protein 2

Poids moléculaire: approx. 53 kDa

ID gène: 26277

NCBI Accession: NP_001092744

UniProt: Q9BSI4

Pathways: Cycle Cellulaire, Telomere Maintenance, Regulation of Carbohydrate Metabolic Process