TDP1 anticorps

N° du produit ABIN2733391

Cet anticorps anti-TDP1 Monoclonal Souris (Clone 4H1) (ABIN2733391) détecte spécifiquement TDP1 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour TDP1 anticorps (ABIN2733391)

Antigène: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TDP1 est non-conjugé

Application: Western Blotting (WB)

Clone: 4H1

Détail du produit anti-TDP1 anticorps

Attributs du produit: Homo sapiens tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 1

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogène: Full length human recombinant protein of human TDP1(NP_060789) produced in HEK293T cell.

Isotype: IgG1

Information d'application

Indications d'application: WB 1:2000,

Commentaires:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur TDP1

Antigène: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Autre désignation: TDP1

Sujet: The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Poids moléculaire: 68.2 kDa

ID gène: 55775

NCBI Accession: NM_018319

HGNC: 55775