Cyclin D1 anticorps (AA 219-238)

N° du produit ABIN2738934

L’anticorps Lapin Polyclonal anti-Cyclin D1 a été validé pour WB. Il convient pour détecter Cyclin D1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Cyclin D1 anticorps (AA 219-238) (ABIN2738934)

Antigène: Cyclin D1 (CCND1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin D1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Cyclin D1 anticorps

Épitope: AA 219-238

Specificité: Human CCND1 / Cyclin D1

Purification: Immunoaffinity purified

Immunogène: Amino acids 219-238 (SPNNFLSCYRTTHFLSRVIK) were used as the immunogen for this Cyclin D1 antibody. This mouse sequence is identical to the related rat sequence, and different from the related human sequence by three amino acids. Percent identity by BLAST analysis: Mouse, Rat (100%), Human, Chimpanzee, Gorilla, Gibbon, Baboon, Monkey (85%), Orangutan, Galago (80%).

Type of Immunogen: Synthetic peptide

Isotype: IgG

Information d'application

Indications d'application: Approved: WB (0.5 - 1 μg/mL)

Usage: D-type cyclins are regarded as essential links between cell environment and the core cell cycle machinery. Cyclin D1, the product of the human gene CCND1, is also known as BCL1. Cyclin D1 expression is regulated by the retinoblastoma protein. Expression of Cyclin D1, but not of cyclins A and E, was induced by transfection of the RB gene into RB-deficient tumor cells. The CCND1 gene can function as an oncogene.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Sterile distilled water

Concentration: Lot specific

Buffer: Lyophilized from PBS, 2.5 % BSA, 0.025 % sodium azide/thimerosal.

Agent conservateur: Sodium azide, Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 1 month or -20°C for longer. Avoid freeze/thaw cycles.

Détails sur Cyclin D1

Antigène: Cyclin D1 (CCND1)

Autre désignation: CCND1 / Cyclin D1

Sujet: Name/Gene ID: CCND1

Synonyms: CCND1, B-cell lymphoma 1 protein, BCL-1 oncogene, B-cell CLL/lymphoma 1, BCL-1, Cyclin D1, G1/S-specific cyclin-D1, U21B31, PRAD1, BCL1, D11S287E, PRAD1 oncogene

ID gène: 595

Pathways: Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, ER-Nucleus Signaling