VASP anticorps
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- Antigène Voir toutes VASP Anticorps
- VASP (Vasodilator-Stimulated phosphoprotein (VASP))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp VASP est non-conjugé
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Application
- Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)
- Specificité
- Recognizes both the 46 kDa (Ser157 dephospho-) and 50 kDa (Ser157 phospho-) form of human VASP.
- Réactivité croisée
- Humain
- Aucune reactivité croisée
- Souris, Rat (Rattus)
- Réactivité croisée (Details)
- Does not cross-react with mouse or rat VASP.
- Ingrédients
- Contains Positive Control: Human platelet protein (500μg) (Prod. No. AG-35T-0001), supplied at 5mg/ml in SDS-stop solution (100mM NaCl, 73mM Tris/HCl pH 6.7, 10mM DTT, 8mM EDTA, 5% [v/v] glycerol, 2% [w/v] SDS, 10μg/ml bromophenol blue sodium salt). Use 5μl (25μg) per lane.
- Immunogène
- Recombinant human VASP fused to a His-tag.
- Top Product
- Discover our top product VASP Anticorps primaire
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- Indications d'application
- Use 5 μL (25 μg) per lane.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Crude serum containing 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. - Date de péremption
- 12 months
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- Antigène
- VASP (Vasodilator-Stimulated phosphoprotein (VASP))
- Autre désignation
- VASP (VASP Produits)
- Synonymes
- anticorps vasp, anticorps MGC80889, anticorps wu:fb23b04, anticorps wu:fk84g05, anticorps zgc:110347, anticorps si:dkey-113g17.1, anticorps si:ch211-202c21.1, anticorps DDBDRAFT_0188463, anticorps DDBDRAFT_0229340, anticorps DDB_0188463, anticorps DDB_0229340, anticorps VASP, anticorps vasodilator stimulated phosphoprotein S homeolog, anticorps vasodilator stimulated phosphoprotein b, anticorps protein enabled, anticorps vasodilator-stimulated phosphoprotein, anticorps vasodilator stimulated phosphoprotein a, anticorps vasodilator stimulated phosphoprotein, anticorps vasp.S, anticorps vaspb, anticorps LOC5573842, anticorps CpipJ_CPIJ004706, anticorps CpipJ_CPIJ004707, anticorps vasP, anticorps vasp, anticorps VASP, anticorps vaspa, anticorps Vasp
- Sujet
- VASP (vasodilator-stimulated phosphoprotein) is a proline-rich protein substrate of cAMP- and cGMP-dependent protein kinases. VASP is an actin-associated protein involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping proteins. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments and it plays a role in actin-based mobility of Listeria monocytogenes in host cells. It regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. VASP phosphorylation is used to monitor the effect of so-called antiplatelet drugs that reduce platelet reactivity and are used to prevent stent thrombosis, strokes and heart attacks in patients. Phosphorylation of VASP at Ser157 causes a mobility shift in SDS gel electrophoresis from 46 to 50 kDa, which has been used as a convenient marker to monitor cyclic nucleotide-dependent protein kinase activity.
- UniProt
- P50552
- Pathways
- TCR Signaling, Regulation of Actin Filament Polymerization, Tube Formation
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