PDE10A anticorps (AA 300-350)

N° du produit ABIN2747045

Cet anticorps Lapin Polyclonal détecte spécifiquement PDE10A dans WB, ELISA, IHC, IP, ICC, IF et CM. Il présente une réactivité avec des échantillons de Humain, Rat, Souris et Singe. Il a été cité dans 12+ publications.

Aperçu rapide pour PDE10A anticorps (AA 300-350) (ABIN2747045)

Antigène: PDE10A (phosphodiesterase 10A (PDE10A))

Reactivité: Humain, Rat, Souris, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDE10A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Confocal Microscopy (CM)

Détail du produit anti-PDE10A anticorps

Épitope: AA 300-350

Purification: Affinity Purified

Immunogène: Synthetic peptide taken within amino acid region 300-350 on human PDE10A2 protein common to all PDE10A variants.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.7 μg/μL

Références pour anticorps anti-PDE10A (ABIN2747045)

Harada, Suzuki, Miura, Hasui, Kamiguchi, Ishii, Taniguchi, Kuroita, Takano, Stepanov, Halldin, Kimura: "Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A." dans: Nuclear medicine and biology, Vol. 42, Issue 2, pp. 146-54, (2015) (PubMed).

Sancesario, Morrone, DAngelo, Castelli, Ferrazzoli, Sica, Martorana, Sorge, Cavaliere, Bernardi, Giorgi: "Levodopa-induced dyskinesias are associated with transient down-regulation of cAMP and cGMP in the caudate-putamen of hemiparkinsonian rats: reduced synthesis or increased catabolism?" dans: Neurochemistry international, Vol. 79, pp. 44-56, (2015) (PubMed).

Mango, Bonito-Oliva, Ledonne, Nisticò, Castelli, Giorgi, Sancesario, Fisone, Berretta, Mercuri: "Phosphodiesterase 10A controls D1-mediated facilitation of GABA release from striato-nigral projections under normal and dopamine-depleted conditions." dans: Neuropharmacology, Vol. 76 Pt A, pp. 127-36, (2014) (PubMed).

Heine, Sygnecka, Scherf, Berndt, Egerland, Hage, Franke: "Phosphodiesterase 2 inhibitors promote axonal outgrowth in organotypic slice co-cultures." dans: Neuro-Signals, Vol. 21, Issue 3-4, pp. 197-212, (2013) (PubMed).

Giorgi, Melchiorri, Nuccetelli, DAngelo, Martorana, Sorge, Castelli, Bernardi, Sancesario: "PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: a key step in parkinsonism physiopathology." dans: Neurobiology of disease, Vol. 43, Issue 1, pp. 293-303, (2011) (PubMed).

Ong, Gribble, Reimann, Lynch, Houslay, Baillie, Furman, Pyne: "The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release." dans: British journal of pharmacology, Vol. 157, Issue 4, pp. 633-44, (2009) (PubMed).

Kruse, Møller, Tibaek, Gammeltoft, Olesen, Kruuse: "PDE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system." dans: Brain research, Vol. 1281, pp. 25-34, (2009) (PubMed).

Bora, Gupta, Malik, Chachra, Sharma, Saini: "Development of a cell-based assay for screening of phosphodiesterase 10A (PDE10A) inhibitors using a stable recombinant HEK-293 cell line expressing high levels of PDE10A." dans: Biotechnology and applied biochemistry, Vol. 49, Issue Pt 2, pp. 129-34, (2008) (PubMed).

Dlaboga, Hajjhussein, ODonnell: "Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B, -4B, and -10A expression in rat striatum." dans: Neuropharmacology, Vol. 54, Issue 4, pp. 745-54, (2008) (PubMed).

Albrecht, Uckert, Oelke, Andersson, Jonas, Tröger, Hedlund: "Immunohistochemical distribution of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human vagina: a potential forensic value?" dans: Journal of forensic and legal medicine, Vol. 14, Issue 5, pp. 270-4, (2007) (PubMed).

Ückert, Oelke, Albrecht, Stief, Jonas, Hedlund: "Immunohistochemical description of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human labia minora." dans: The journal of sexual medicine, Vol. 4, Issue 3, pp. 602-608, (2007) (PubMed).

Uckert, Oelke, Waldkirch, Stief, Albrecht, Tröger, Jonas, Andersson, Hedlund: "Cyclic adenosine monophosphate and cyclic guanosine monophosphate-phosphodiesterase isoenzymes in human vagina: relation to nitric oxide synthase isoforms and vasoactive intestinal polypeptide-containing nerves." dans: Urology, Vol. 65, Issue 3, pp. 604-10, (2005) (PubMed).

Détails sur PDE10A

Antigène: PDE10A (phosphodiesterase 10A (PDE10A))

Autre désignation: PDE10A

UniProt: Q9Y233

Pathways: cAMP Metabolic Process