Influenza Nucleoprotein anticorps (Influenza B Virus) (AA 1-560) (HRP)

N° du produit ABIN2754745

L’anticorps Lapin Polyclonal anti- a été validé pour ELISA et WB. Il convient pour détecter dans des échantillons de Influenza B Virus.

Aperçu rapide pour Influenza Nucleoprotein anticorps (Influenza B Virus) (AA 1-560) (HRP) (ABIN2754745)

Antigène: Influenza Nucleoprotein (NP)

Reactivité: Influenza B Virus

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: HRP

Application: ELISA, Western Blotting (WB)

Détail du produit

Épitope: AA 1-560

Purification: Caprylic Acid Ammonium Sulfate Precipitation purified

Immunogène: Recombinant Influenza B virus Nucleoprotein protein(1-560aa)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C/-80 °C

Détail du antigène

Antigène: Influenza Nucleoprotein (NP)

Autre désignation: Influenza Nucleoprotein

Classe de substances: Influenza Protein

Sujet: Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein\'s nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein\'s nuclear localization signals, targeting the RNP to the nucleus.

UniProt: P04665