Lactate Dehydrogenase A anticorps (N-Term)

N° du produit ABIN2774085

Cet anticorps Lapin Polyclonal détecte spécifiquement Lactate Dehydrogenase A dans WB et IHC. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Lapin, Boeuf (Vache), Cheval, Chien, Cobaye, Chévre et Mouton. Il a été cité dans 3+ publications.

Aperçu rapide pour Lactate Dehydrogenase A anticorps (N-Term) (ABIN2774085)

Antigène: Lactate Dehydrogenase A (LDHA)

Reactivité: Humain, Souris, Rat, Lapin, Boeuf (Vache), Cheval, Chien, Cobaye, Chévre, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Lactate Dehydrogenase A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Lactate Dehydrogenase A anticorps

Épitope: N-Term

Fonction: LDHA Antibody - N-terminal region

Séquence: ATLKDQLIYN LLKEEQTPQN KITVVGVGAV GMACAISILM KDLADELALV

Homologie: Cow: 86%, Dog: 86%, Goat: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 93%, Sheep: 86%

Attributs du produit: This is a rabbit polyclonal antibody against LDHA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human LDHA

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP54776-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Lactate Dehydrogenase A (ABIN2774085)

Schönrogge, Kerndl, Zhang, Kumstel, Vollmar, Zechner: "α-cyano-4-hydroxycinnamate impairs pancreatic cancer cells by stimulating the p38 signaling pathway." dans: Cellular signalling, Vol. 47, pp. 101-108, (2018) (PubMed).

Zechner, Bürtin, Albert, Zhang, Kumstel, Schönrogge, Graffunder, Shih, Müller, Radecke, Jaster, Vollmar: "Intratumoral heterogeneity of the therapeutical response to gemcitabine and metformin." dans: Oncotarget, Vol. 7, Issue 35, pp. 56395-56407, (2018) (PubMed).

Listerman, Bledau, Grishina, Neugebauer: "Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III." dans: PLoS genetics, Vol. 3, Issue 11, pp. e212, (2008) (PubMed).

Détails sur Lactate Dehydrogenase A

Antigène: Lactate Dehydrogenase A (LDHA)

Autre désignation: LDHA

Sujet:

Background Information: The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene.

Gene Name: lactate dehydrogenase A

Alternative Symbols: LDHM, GSD11, PIG19, HEL-S-133P

Protein Name: L-lactate dehydrogenase A chain

Poids moléculaire: 37 kDa

ID gène: 3939

NCBI Accession: NP_005557

UniProt: P00338

Pathways: L'effet Warburg