INPP5D anticorps (C-Term)

N° du produit ABIN2774303

L’anticorps anti-INPP5D Polyclonal Lapin est utilisé pour la détection de INPP5D dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Porc et Lapin. Il a été validé pour WB.

Aperçu rapide pour INPP5D anticorps (C-Term) (ABIN2774303)

Antigène: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INPP5D est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-INPP5D anticorps

Épitope: C-Term

Fonction: INPP5D Antibody - C-terminal region

Séquence: PPTPTPRPPL PVKSPAVLHL QHSKGRDYRD NTELPHHGKH RPEEGPPGPL

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against INPP5D. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61033-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur INPP5D

Antigène: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Autre désignation: INPP5D

Sujet:

Background Information: This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene Name: Inositol polyphosphate-5-phosphatase, 145 kDa

Alternative Symbols: SHIP, SHIP1, SHIP-1, hp51CN, SIP-145, p150Ship

Protein Name: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

Poids moléculaire: 134 kDa

ID gène: 3635

NCBI Accession: NP_001017915

UniProt: Q92835

Pathways: TCR Signaling, BCR Signaling, L'effet Warburg