INPP5D anticorps (C-Term)
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- Antigène Voir toutes INPP5D Anticorps
- INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
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Épitope
- C-Term
- Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Porc
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp INPP5D est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- PPTPTPRPPL PVKSPAVLHL QHSKGRDYRD NTELPHHGKH RPEEGPPGPL
- Homologie
- Cow: 86%, Dog: 86%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against INPP5D. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product INPP5D Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 1189 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
- Autre désignation
- INPP5D (INPP5D Produits)
- Synonymes
- anticorps INPP5D, anticorps 256.t00004, anticorps 13.t00027, anticorps ship, anticorps ship1, anticorps AI323613, anticorps SHIP, anticorps SHIP-1, anticorps SHIP1, anticorps s-SHIP, anticorps SIP-145, anticorps hp51CN, anticorps inositol polyphosphate-5-phosphatase D, anticorps phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, anticorps inositol polyphosphate 5-phosphatase, anticorps inositol polyphosphate-5-phosphatase D L homeolog, anticorps INPP5D, anticorps LOC100446045, anticorps inpp5d, anticorps EHI_159880, anticorps EHI_153490, anticorps inpp5d.L, anticorps LOC100380693, anticorps Inpp5d
- Sujet
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This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: MGC104855, MGC142140, MGC142142, SHIP, SHIP1, SIP-145, hp51CN
Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-9, KRTAP10-7, KRT40, KHDRBS3, KRT31, DAB1, SH3KBP1, XIAP, INPPL1, LRRK1, SHC1, PTPN11, UBASH3B, CD2AP, SYK, NCK1, GRB2, CBL, UBC, ARAP1, BCR, CLYBL, MME, EPOR, TRIP10, CD300LF, DOK3, LILRB4, INPP5D, FCGR2B, GAB2, DOK2, GAB1, D
Protein Size: 1189 - Poids moléculaire
- 131 kDa
- ID gène
- 3635
- NCBI Accession
- NM_001017915, NP_001017915
- UniProt
- Q92835
- Pathways
- TCR Signaling, BCR Signaling, L'effet Warburg
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