Caspase 3 anticorps (N-Term)

N° du produit ABIN2774596

Cité dans 2 publications. Cet anticorps anti-Caspase 3 Polyclonal Lapin (ABIN2774596) détecte spécifiquement Caspase 3 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Rat, Boeuf (Vache), Chien, Porc, Lapin, Cobaye et Cheval.

Aperçu rapide pour Caspase 3 anticorps (N-Term) (ABIN2774596)

Antigène: Caspase 3 (CASP3)

Reactivité: Humain, Rat, Boeuf (Vache), Chien, Porc, Lapin, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Caspase 3 anticorps

Épitope: N-Term

Fonction: CASP3 Antibody - N-terminal region

Séquence: MENTENSVDS KSIKNLEPKI IHGSESMDSG ISLDNSYKMD YPEMGLCIII

Homologie: Cow: 84%, Dog: 84%, Guinea Pig: 84%, Horse: 92%, Human: 100%, Pig: 92%, Rabbit: 84%, Rat: 84%

Attributs du produit: This is a rabbit polyclonal antibody against CASP3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CASP3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Caspase 3 (ABIN2774596)

Korkmaz-Icöz, Sistori, Loganathan, Sayour, Brlecic, Radovits, Brune, Karck, Szabó: "Bone Marrow Culture-Derived Conditioned Medium Recovers Endothelial Function of Vascular Grafts following In Vitro Ischemia/Reperfusion Injury in Diabetic Rats." dans: Stem cells international, Vol. 2022, pp. 7019088, (2022) (PubMed).

Jeong, Lee, Shim, Hur: "A scaffold-free surface culture of B16F10 murine melanoma cells based on magnetic levitation." dans: Cytotechnology, Vol. 68, Issue 6, pp. 2323-2334, (2016) (PubMed).

Détails sur Caspase 3

Antigène: Caspase 3 (CASP3)

Autre désignation: CASP3

Sujet:

Background Information: CASP3 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Gene Name: Caspase 3, apoptosis-related cysteine peptidase

Alternative Symbols: CPP32, SCA-1, CPP32B

Protein Name: Caspase-3

Poids moléculaire: 32 kDa

ID gène: 836

NCBI Accession: NP_004337

UniProt: P42574

Pathways: Apoptose, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation