RNF139 anticorps (N-Term)

N° du produit ABIN2774685

Cet anticorps Lapin Polyclonal détecte spécifiquement RNF139 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Lapin et Cheval.

Aperçu rapide pour RNF139 anticorps (N-Term) (ABIN2774685)

Antigène: RNF139 (Ring Finger Protein 139 (RNF139))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Lapin, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF139 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RNF139 anticorps

Épitope: N-Term

Fonction: RNF139 Antibody - N-terminal region

Séquence: SQRSLFKFYT YSSAFLLAAT SVLVNYYASL HIDFYGAYNT SAFGIELLPR

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 87%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against RNF139. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human RNF139

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP43092-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur RNF139

Antigène: RNF139 (Ring Finger Protein 139 (RNF139))

Autre désignation: RNF139

Sujet:

Background Information: RNF139 is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.

Gene Name: Ring finger protein 139

Alternative Symbols: RCA1, TRC8, HRCA1

Protein Name: E3 ubiquitin-protein ligase RNF139

Poids moléculaire: 76 kDa

ID gène: 11236

NCBI Accession: NP_009149

UniProt: Q8WU17