DTX2 anticorps (C-Term)

N° du produit ABIN2774772

Détail du produit anti-DTX2 anticorps

Antigène: DTX2 (Deltex Homolog 2 (DTX2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Poisson zèbre (Danio rerio), Lapin, Chévre, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DTX2 est non-conjugé

Application: Western Blotting (WB)

Séquence: EDCGTILIVY SIPHGIQGPE HPNPGKPFTA RGFPRQCYLP DNAQGRKVLE

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against DTX2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human DTX2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 575 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur DTX2

Antigène: DTX2 (Deltex Homolog 2 (DTX2))

Autre désignation: DTX2 (DTX2 Produits)

Synonymes: anticorps RNF58, anticorps 2610524D08Rik, anticorps AA408415, anticorps AU022494, anticorps Deltex2, anticorps dtx2, anticorps deltex E3 ubiquitin ligase 2, anticorps probable E3 ubiquitin-protein ligase DTX2, anticorps deltex 2, E3 ubiquitin ligase, anticorps deltex 2, E3 ubiquitin ligase S homeolog, anticorps DTX2, anticorps Dtx2, anticorps LOC735784, anticorps LOC747633, anticorps dtx2, anticorps dtx2.S

Sujet: DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. DTX2 probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context and mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. It also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Alias Symbols: KIAA1528, MGC71098, RNF58
Protein Interaction Partner: KRTAP26-1, RFX6, KLC3, GLYCTK, DTX2, RIMBP3, C1orf94, NCALD, PLEKHF2, TRIM54, EIF4ENIF1, ALKBH4, UBE2D4, HPCAL4, SPG21, SEC22A, SPAG8, STX12, NCS1, FAM168A, RBPMS, SEC23B, ABHD16A, VSNL1, SUMO1, UBE2D3, UBE2D1, UBC, TRIP6, QARS, HDC, GOLGA2, FHL2, ARNT2,
Protein Size: 575

Poids moléculaire: 62 kDa

ID gène: 113878

NCBI Accession: NM_001102596, NP_001096066

UniProt: Q6XM87

Pathways: Signalisation Notch