Connexin 43/GJA1 anticorps (Middle Region)

N° du produit ABIN2774852

Cet anticorps anti-Connexin 43/GJA1 est un anticorps Lapin Polyclonal détectant Connexin 43/GJA1 dans WB. Adapté pour Humain, Rat, Souris, Chien, Boeuf (Vache), Lapin, Cobaye et Cheval.

Aperçu rapide pour Connexin 43/GJA1 anticorps (Middle Region) (ABIN2774852)

Antigène: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Reactivité: Humain, Rat, Souris, Chien, Boeuf (Vache), Lapin, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Connexin 43/GJA1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Connexin 43/GJA1 anticorps

Épitope: Middle Region

Séquence: GSTISNSHAQ PFDFPDDNQN SKKLAAGHEL QPLAIVDQRP SSRASSRASS

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against GJA1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human GJA1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 382 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Connexin 43/GJA1

Antigène: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Autre désignation: GJA1

Sujet: Gap junction protein, alpha 1 is a member of the connexin gene family and a component of gap junctions. Gap junctions are composed of arrays of intercellular channels and provide a route for the diffusion of materials of low molecular weight from cell to cell. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5. This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CX43, DFNB38, GJAL, ODDD, HSS, AVSD3, HLHS1
Protein Interaction Partner: UBC, STAMBP, EPS15, UBQLN4, PSMD4, PSMD2, S100A1, GJA1, CNST, NEDD4, TJP1, HGS, TSG101, SGSM3, GJA5, MAPK7, MAPK3, CAV1, CSNK1D, SRC, PRKCG, PRKCE, PRKCB, PRKCA, MAPK1, NOV, CSK, GJA3,
Protein Size: 382

Poids moléculaire: 43 kDa

ID gène: 2697

NCBI Accession: NM_000165, NP_000156

UniProt: P17302

Pathways: Signalisation MAPK, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization