MCM2 anticorps (Middle Region)

N° du produit ABIN2774881

Cet anticorps Lapin Polyclonal détecte spécifiquement MCM2 dans WB. Il présente une réactivité envers Humain, Souris, Rat, Chien, Cheval, Lapin, Boeuf (Vache), Cobaye et Poisson zèbre (Danio rerio).

Aperçu rapide pour MCM2 anticorps (Middle Region) (ABIN2774881)

Antigène: MCM2 (Minichromosome Maintenance Complex Component 2 (MCM2))

Reactivité: Humain, Souris, Rat, Chien, Cheval, Lapin, Boeuf (Vache), Cobaye, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCM2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MCM2 anticorps

Épitope: Middle Region

Séquence: NNELLLFILK QLVAEQVTYQ RNRFGAQQDT IEVPEKDLVD KARQINIHNL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against MCM2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human MCM2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 904 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MCM2

Antigène: MCM2 (Minichromosome Maintenance Complex Component 2 (MCM2))

Autre désignation: MCM2

Sujet: This protein is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: BM28, CCNL1, CDCL1, D3S3194, KIAA0030, MGC10606, MITOTIN, cdc19
Protein Interaction Partner: HUWE1, MCM6, CHFR, SUMO2, MCMBP, UBC, SUMO1, MDM2, MCM7, MCM4, HSP90AB1, ACLY, PRRC1, HYOU1, CAP1, NCL, POLA1, TONSL, SNF8, ELL, TCEA1, POLR2A, CDK6, CDK4, CDC6, MCM10, ORC6, CCNB2, VCAM1, P2RX4, ORC5, ORC2, MCM5, MCM3, ITGA4, FN1, CSNK2A1, CDKN2A, DBF4,
Protein Size: 904

Poids moléculaire: 102 kDa

ID gène: 4171

NCBI Accession: NM_004526, NP_004517

UniProt: P49736

Pathways: Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA