RUNX2 anticorps (Middle Region)

N° du produit ABIN2774905

Cet anticorps Lapin Polyclonal détecte spécifiquement RUNX2 dans WB. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye et Lapin et a été mentionné dans 1 publication.

Aperçu rapide pour RUNX2 anticorps (Middle Region) (ABIN2774905)

Antigène: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RUNX2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RUNX2 anticorps

Épitope: Middle Region

Séquence: DTATSDFCLW PSTLSKKSQA GASELGPFSD PRQFPSISSL TESRFSNPRM

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against RUNX2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human RUNX2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 521 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-RUNX2 (ABIN2774905)

Schuchardt, Tölle, Prüfer, Prüfer, Huang, Jankowski, Jankowski, Zidek, van der Giet: "Uridine adenosine tetraphosphate activation of the purinergic receptor P2Y enhances in vitro vascular calcification." dans: Kidney international, Vol. 81, Issue 3, pp. 256-65, (2012) (PubMed).

Détails sur RUNX2

Antigène: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Autre désignation: RUNX2

Sujet: RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis, acting as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants, encoding different protein isoforms, result from alternate promoter use as well as alternate splicing.
Alias Symbols: CCD, AML3, CCD1, OSF2, CBFA1, OSF-2, PEA2aA, PEBP2A1, PEBP2A2, PEBP2aA, PEBP2aA1
Protein Interaction Partner: HDAC7, HDAC6, TP53, UBC, RB1, PML, HIF1A, SMURF1, SMAD1, SMURF2, HIVEP3, WWP1, FHL2, UBTF, SUV39H1, HDAC1, STAT3, SMAD3, RBM14, SOX9, NR0B2, EP300, HDAC5, HDAC4, HDAC3, CREBBP, XRCC5, HES1, XRCC6, BMPR1A, KAT2B, TLE1, YAP1, KAT6B, TAF1A, AXIN1, SMAD6, MAP
Protein Size: 521

Poids moléculaire: 57 kDa

ID gène: 860

NCBI Accession: NM_001024630, NP_001019801

UniProt: Q13950