DKK4 anticorps (C-Term)

N° du produit ABIN2775398

Détail du produit anti-DKK4 anticorps

Antigène: DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Chien, Cobaye, Lapin, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DKK4 est non-conjugé

Application: Western Blotting (WB)

Séquence: RTSDCGPGLC CARHFWTKIC KPVLREGQVC SRRGHKDTAQ APEIFQRCDC

Homologie: Dog: 93%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 79%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against Dkk4. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 221 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur DKK4

Antigène: DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))

Autre désignation: Dkk4 (DKK4 Produits)

Synonymes: anticorps DKK-4, anticorps Dkk-4, anticorps RGD1563172, anticorps dickkopf WNT signaling pathway inhibitor 4, anticorps DKK4, anticorps Dkk4

Sujet: Dkk4 antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Alias Symbols: Dkk-4, MGC25705
Protein Size: 221

Poids moléculaire: 24 kDa

ID gène: 234130

NCBI Accession: NM_145592, NP_663567

UniProt: Q8VEJ3

Pathways: Signalisation WNT