ATG4A anticorps (Middle Region)

N° du produit ABIN2775554

Cet anticorps Lapin Polyclonal détecte spécifiquement ATG4A dans WB. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Porc, Lapin et Poisson zèbre (Danio rerio) et a été mentionné dans 1 publication.

Aperçu rapide pour ATG4A anticorps (Middle Region) (ABIN2775554)

Antigène: ATG4A (Autophagy related 4A Cysteine Peptidase (ATG4A))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Porc, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG4A est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ATG4A anticorps

Épitope: Middle Region

Séquence: PQSLGALGGK PNNAYYFIGF LGDELIFLDP HTTQTFVDTE ENGTVNDQTF

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against ATG4A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ATG4A

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 398 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ATG4A (ABIN2775554)

Bortnik, Choutka, Horlings, Leung, Baker, Lebovitz, Dragowska, Go, Bally, Minchinton, Gelmon, Gorski: "Identification of breast cancer cell subtypes sensitive to ATG4B inhibition." dans: Oncotarget, Vol. 7, Issue 41, pp. 66970-66988, (2016) (PubMed).

Détails sur ATG4A

Antigène: ATG4A (Autophagy related 4A Cysteine Peptidase (ATG4A))

Autre désignation: ATG4A

Sujet: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. ATG4A is a member of the autophagin protein family. ATG4A is also designated as a member of the C-54 family of cysteine proteases.
Alias Symbols: APG4A, AUTL2
Protein Interaction Partner: CDKL3, GABARAPL1, GABARAPL2, ATG101, MAP1LC3B,
Protein Size: 398

Poids moléculaire: 45 kDa

ID gène: 115201

NCBI Accession: NM_052936, NP_443168

UniProt: Q8WYN0

Pathways: Autophagy