RGS18 anticorps (N-Term)

N° du produit ABIN2775584

Cet anticorps anti-RGS18 Polyclonal Lapin (ABIN2775584) détecte spécifiquement RGS18 dans WB. L’anticorps est réactif avec des échantillons de Humain, Rat, Souris, Chien, Cobaye, Cheval, Boeuf (Vache) et Lapin.

Aperçu rapide pour RGS18 anticorps (N-Term) (ABIN2775584)

Antigène: RGS18 (Regulator of G-Protein Signalling 18 (RGS18))

Reactivité: Humain, Rat, Souris, Chien, Cobaye, Cheval, Boeuf (Vache), Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RGS18 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RGS18 anticorps

Épitope: N-Term

Fonction: RGS18 Antibody - N-terminal region

Séquence: METTLLFFSQ INMCESKEKT FFKLIHGSGK EETSKEAKIR AKEKRNRLSL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against RGS18. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human RGS18

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8110229

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur RGS18

Antigène: RGS18 (Regulator of G-Protein Signalling 18 (RGS18))

Autre désignation: RGS18

Sujet:

Background Information: RGS18 is a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Gene Name: Regulator of G-protein signaling 18

Alternative Symbols: RGS13

Protein Name: Regulator of G-protein signaling 18

Poids moléculaire: 26kDa

ID gène: 64407

NCBI Accession: NP_570138

UniProt: Q9NS28

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling