NFX1 anticorps (N-Term)

N° du produit ABIN2776010

Cet anticorps anti-NFX1 Polyclonal Lapin (ABIN2776010) détecte spécifiquement NFX1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye, Cheval et Porc.

Aperçu rapide pour NFX1 anticorps (N-Term) (ABIN2776010)

Antigène: NFX1 (Nuclear Transcription Factor, X-Box Binding 1 (NFX1))

Reactivité: Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye, Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NFX1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-NFX1 anticorps

Épitope: N-Term

Fonction: NFX1 Antibody - N-terminal region

Séquence: MAEAPPVSGT FKFNTDAAEF IPQEKKNSGL NCGTQRRLDS NRIGRRNYSS

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 85%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against NFX1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human NFX1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP34770-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur NFX1

Antigène: NFX1 (Nuclear Transcription Factor, X-Box Binding 1 (NFX1))

Autre désignation: NFX1

Sujet:

Background Information: NFX1 binds to the X-box motif of MHC class II genes and represses their expression. NFX1 may play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. NFX1 mediates E2-dependent ubiquitination.MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.

Gene Name: Nuclear transcription factor, X-box binding 1

Alternative Symbols: NFX2, Tex42, TEG-42

Protein Name: Transcriptional repressor NF-X1

Poids moléculaire: 113kDa

ID gène: 4799

NCBI Accession: NP_667344

UniProt: Q12986