FZD4 anticorps (Middle Region)

N° du produit ABIN2776715

Cet anticorps anti-FZD4 est un anticorps Lapin Polyclonal détectant FZD4 dans WB et IHC. Adapté pour Humain, Souris, Rat, Boeuf (Vache), Cheval et Cobaye. Ce Primary Antibody a été cité dans 3+ publications.

Aperçu rapide pour FZD4 anticorps (Middle Region) (ABIN2776715)

Antigène: FZD4 (Frizzled Family Receptor 4 (FZD4))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cheval, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZD4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-FZD4 anticorps

Épitope: Middle Region

Séquence: GITSGMWIWS AKTLHTWQKC SNRLVNSGKV KREKRGNGWV KPGKGSETVV

Homologie: Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against FZD4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human FZD4

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 537 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-FZD4 (ABIN2776715)

Wang, Pawlak, Johnson, Belknap, Eades, Stack, Cousin, Black: "Impact of laminitis on the canonical Wnt signaling pathway in basal epithelial cells of the equine digital laminae." dans: PLoS ONE, Vol. 8, Issue 2, pp. e56025, (2013) (PubMed).

McIver, Stanger, Santarelli, Roman, Nixon, McLaughlin: "A unique combination of male germ cell miRNAs coordinates gonocyte differentiation." dans: PLoS ONE, Vol. 7, Issue 4, pp. e35553, (2012) (PubMed).

Gonzalez, Fernandez-Martos, Gonzalez-Fernandez, Arenas, Rodriguez: "Spatio-temporal expression pattern of frizzled receptors after contusive spinal cord injury in adult rats." dans: PLoS ONE, Vol. 7, Issue 12, pp. e50793, (2012) (PubMed).

Détails sur FZD4

Antigène: FZD4 (Frizzled Family Receptor 4 (FZD4))

Autre désignation: FZD4

Sujet: FZD4 is a member of the frizzled family. Members of this family are seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: EVR1, FEVR, FZD4S, Fz-4, FzE4, GPCR, MGC34390, CD344
Protein Interaction Partner: UBC, NDP, ZNRF3, BAG6, MAGI3, DLG2, DLG4, DVL2, DLG1, ARRB2,
Protein Size: 537

Poids moléculaire: 60 kDa

ID gène: 8322

NCBI Accession: NM_012193, NP_036325

UniProt: Q9ULV1

Pathways: Signalisation WNT, Hormone Transport, Sensory Perception of Sound