ATF6B anticorps (Middle Region)

N° du produit ABIN2777358

Cet anticorps Lapin Polyclonal détecte spécifiquement ATF6B dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Porc, Boeuf (Vache), Cheval et Chien.

Aperçu rapide pour ATF6B anticorps (Middle Region) (ABIN2777358)

Antigène: ATF6B (Activating Transcription Factor 6 beta (ATF6B))

Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache), Cheval, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATF6B est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ATF6B anticorps

Épitope: Middle Region

Fonction: CREBL1 Antibody - middle region

Séquence: FNRTESLRLA DELSGWVQRH QRGRRKIPQR AQERQKSQPR KKSPPVKAVP

Homologie: Cow: 86%, Dog: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 85%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against CREBL1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CREBL1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8093911

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur ATF6B

Antigène: ATF6B (Activating Transcription Factor 6 beta (ATF6B))

Autre désignation: CREBL1

Sujet:

Background Information: ATF6B(CREBL1) is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. ATF6B is normally found in the membrane of the endoplasmic reticulum, however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip superfamily of transcription factors. It localizes to both the cytoplasm and the nucleus. The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Activating transcription factor 6 beta

Alternative Symbols: G13, CREBL1, CREB-RP

Protein Name: Cyclic AMP-dependent transcription factor ATF-6 beta

Poids moléculaire: 77kDa

ID gène: 1388

NCBI Accession: NP_004372

UniProt: Q99941

Pathways: Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction