Tumor Protein p73 anticorps (N-Term)

N° du produit ABIN2777952

Cet anticorps anti-Tumor Protein p73 est un anticorps Lapin Polyclonal détectant Tumor Protein p73 dans WB. Adapté pour Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Poisson zèbre (Danio rerio) et Porc.

Aperçu rapide pour Tumor Protein p73 anticorps (N-Term) (ABIN2777952)

Antigène: Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Poisson zèbre (Danio rerio), Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tumor Protein p73 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Tumor Protein p73 anticorps

Épitope: N-Term

Séquence: AQSTATSPDG GTTFEHLWSS LEPDSTYFDL PQSSRGNNEV VGGTDSSMDV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Human: 100%, Mouse: 93%, Pig: 92%, Rat: 93%, Zebrafish: 92%

Attributs du produit: This is a rabbit polyclonal antibody against TP73. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human TP73

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 636 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Tumor Protein p73

Antigène: Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))

Autre désignation: TP73

Sujet: TP73 belongs to the p53 family. It participates in the apoptotic response to DNA damage. When overproduced, it activates transcription from p53-responsive promoters and induces apoptosis. TP53 may be a tumor suppressor protein. This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms, however, the biological validity and the full-length nature of most variants have not been determined.
Alias Symbols: P73
Protein Interaction Partner: FUS, YAP1, WWOX, UBC, TRIM32, SOX2, PFDN5, MYC, EP300, CDK2, CCNE1, CCNB1, CCNA2, CCND1, XPO1, PIN1, AURKA, PRKACA, MAD2L1, HSPA9, CDC20, TP53BP1, RBX1, DDB1, RCHY1, KAT2B, NEDD8, MDM2, IKBKB, DAXX, CHUK, BUB1B, BRCA1, TNK2, AMPH, CREBBP, KAT5, CEP131, MD
Protein Size: 636

Poids moléculaire: 69 kDa

ID gène: 7161

NCBI Accession: NM_005427, NP_005418

UniProt: O15350

Pathways: Regulation of Cell Size, Positive Regulation of Response to DNA Damage Stimulus