Cholesterol Esterase anticorps (C-Term)

N° du produit ABIN2778160

Cet anticorps Lapin Polyclonal détecte spécifiquement Cholesterol Esterase dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Cheval et Porc.Il a été cité dans 1 publication.

Aperçu rapide pour Cholesterol Esterase anticorps (C-Term) (ABIN2778160)

Antigène: Cholesterol Esterase (CEL)

Reactivité: Humain, Souris, Rat, Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cholesterol Esterase est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Cholesterol Esterase anticorps

Épitope: C-Term

Fonction: CEL Antibody - C - terminal region

Séquence: VTPTGDSETA PVPPTGDSGA PPVPPTGDSE AAPVPPTDDS KEAQMPAVIR

Homologie: Horse: 77%, Human: 100%, Mouse: 77%, Pig: 85%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CEL. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C - terminal region of human CEL

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP33857-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Cholesterol Esterase (ABIN2778160)

Panicot-Dubois, Thomas, Furie, Furie, Lombardo, Dubois: "Bile salt-dependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans." dans: The Journal of clinical investigation, Vol. 117, Issue 12, pp. 3708-19, (2007) (PubMed).

Détails sur Cholesterol Esterase

Antigène: Cholesterol Esterase (CEL)

Autre désignation: CEL

Sujet:

Background Information: CEL catalyzes fat and vitamin absorption. CEL acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Carboxyl ester lipase (bile salt-stimulated lipase)

Alternative Symbols: BAL, FAP, BSDL, BSSL, CELL, FAPP, LIPA, CEase, MODY8

Protein Name: Bile salt-activated lipase

Poids moléculaire: 80kDa

ID gène: 1056

NCBI Accession: NP_001798

UniProt: P19835

Pathways: Lipid Metabolism