COPS2 anticorps (N-Term)

N° du produit ABIN2778315

L’anticorps anti-COPS2 Polyclonal Lapin est utilisé pour la détection de COPS2 dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Poisson zèbre (Danio rerio), Chien, Cheval, Lapin, Cobaye et Saccharomyces cerevisiae. Il a été validé pour WB et IHC.

Aperçu rapide pour COPS2 anticorps (N-Term) (ABIN2778315)

Antigène: COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Poisson zèbre (Danio rerio), Chien, Cheval, Lapin, Cobaye, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-COPS2 anticorps

Épitope: N-Term

Fonction: COPS2 Antibody - N-terminal region

Séquence: SDMEDDFMCD DEEDYDLEYS EDSNSEPNVD LENQYYNSKA LKEDDPKAAL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 85%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against COPS2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human COPS2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP34188-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur COPS2

Antigène: COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))

Autre désignation: COPS2

Sujet:

Targeted Subunit: 2

Background Information: COPS2 is an essential component of the COP9 signalosome complex (CSN). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. COPS2 is involved in early stage of neuronal differentiation via its interaction with NIF3L1.

Gene Name: COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)

Alternative Symbols: CSN2, SGN2, ALIEN, TRIP15

Protein Name: COP9 signalosome complex subunit 2

Poids moléculaire: 52kDa

ID gène: 9318

NCBI Accession: NP_004227

UniProt: P61201

Pathways: Cycle Cellulaire