PRMT5 anticorps (N-Term)

N° du produit ABIN2778654

L’anticorps Lapin Polyclonal anti-PRMT5 a été validé pour WB et IHC. Il convient pour détecter PRMT5 dans des échantillons de Humain, Souris, Rat, Chien, Cheval, Lapin, Boeuf (Vache), Cobaye et Poisson zèbre (Danio rerio).

Aperçu rapide pour PRMT5 anticorps (N-Term) (ABIN2778654)

Antigène: PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))

Reactivité: Humain, Souris, Rat, Chien, Cheval, Lapin, Boeuf (Vache), Cobaye, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRMT5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-PRMT5 anticorps

Épitope: N-Term

Séquence: FDFLCMPVFH PRFKREFIQE PAKNRPGPQT RSDLLLSGRD WNTLIVGKLS

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%

Attributs du produit: This is a rabbit polyclonal antibody against PRMT5. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PRMT5

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 620 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PRMT5

Antigène: PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))

Autre désignation: PRMT5

Sujet: PRMT5 methylates specific arginine residues in the small nuclear ribonucleoproteins Sm D1 and Sm D3 to monomethylarginine and to symmetrical dimethylarginines (sDMAs). It methylates SUPT5H. PRMT5 plays a role in the assembly of snRNP core particles and may play a role in cytokine-activated transduction pathways. It negatively regulates cyclin E1 promoter activity and cellular proliferation and May regulate the SUPT5H transcriptional elongation properties. It may be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. PRMT5 methylates histone H2A/H4 'Arg-3' during germ cell development and methylates histone H3 'Arg-8', which may repress transcription.
Alias Symbols: JBP1, SKB1, IBP72, SKB1Hs, HRMT1L5
Protein Interaction Partner: UBC, TP53, ING2, PRDM1, NFE4, WDR5, SUMO2, WWOX, CDYL2, LENG8, LDHAL6B, PRPF38A, ING5, ZNF436, WDR77, GRHL3, TRIB3, RSRP1, LUC7L, RBM23, GTPBP2, H3F3C, FOXK1, ZUFSP, FAM76B, NUDCD2, MAGEB2, NELFCD, COPS4, COPS7A, DCAF8, SPAG8, SLU7, MCRS1, CUL4A, ZNF2, YW
Protein Size: 620

Poids moléculaire: 68 kDa

ID gène: 10419

NCBI Accession: NM_001039619, NP_001034708

UniProt: O14744

Pathways: Chromatin Binding, Regulation of Muscle Cell Differentiation, Ribonucleoprotein Complex Subunit Organization, Skeletal Muscle Fiber Development