PRMT5 anticorps (N-Term)

N° du produit ABIN2778654

Détail du produit anti-PRMT5 anticorps

Antigène: PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Lapin, Cheval, Boeuf (Vache), Cobaye, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRMT5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: FDFLCMPVFH PRFKREFIQE PAKNRPGPQT RSDLLLSGRD WNTLIVGKLS

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%

Attributs du produit: This is a rabbit polyclonal antibody against PRMT5. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PRMT5

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 620 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PRMT5

Antigène: PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))

Autre désignation: PRMT5 (PRMT5 Produits)

Synonymes: anticorps HRMT1L5, anticorps IBP72, anticorps JBP1, anticorps SKB1, anticorps SKB1Hs, anticorps Jbp1, anticorps Skb1, anticorps si:zc14a17.2, anticorps skb1, anticorps wu:fb95f10, anticorps zgc:110669, anticorps hsl7, anticorps DDBDRAFT_0187422, anticorps DDBDRAFT_0235403, anticorps DDB_0187422, anticorps DDB_0235403, anticorps NV18830, anticorps jbp1, anticorps ibp72, anticorps skb1hs, anticorps hrmt1l5, anticorps protein arginine methyltransferase 5, anticorps protein arginine N-methyltransferase 5, anticorps protein arginine methyltransferase 5 L homeolog, anticorps putative arginine N-methyltransferase, type II, anticorps Skb1 family protein, anticorps Protein arginine N-methyltransferase 5, anticorps PRMT5, anticorps Prmt5, anticorps prmt5, anticorps prmt5.L, anticorps LOC100115766, anticorps prmt-5

Sujet: PRMT5 methylates specific arginine residues in the small nuclear ribonucleoproteins Sm D1 and Sm D3 to monomethylarginine and to symmetrical dimethylarginines (sDMAs). It methylates SUPT5H. PRMT5 plays a role in the assembly of snRNP core particles and may play a role in cytokine-activated transduction pathways. It negatively regulates cyclin E1 promoter activity and cellular proliferation and May regulate the SUPT5H transcriptional elongation properties. It may be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. PRMT5 methylates histone H2A/H4 'Arg-3' during germ cell development and methylates histone H3 'Arg-8', which may repress transcription.
Alias Symbols: JBP1, SKB1, IBP72, SKB1Hs, HRMT1L5
Protein Interaction Partner: UBC, TP53, ING2, PRDM1, NFE4, WDR5, SUMO2, WWOX, CDYL2, LENG8, LDHAL6B, PRPF38A, ING5, ZNF436, WDR77, GRHL3, TRIB3, RSRP1, LUC7L, RBM23, GTPBP2, H3F3C, FOXK1, ZUFSP, FAM76B, NUDCD2, MAGEB2, NELFCD, COPS4, COPS7A, DCAF8, SPAG8, SLU7, MCRS1, CUL4A, ZNF2, YW
Protein Size: 620

Poids moléculaire: 68 kDa

ID gène: 10419

NCBI Accession: NM_001039619, NP_001034708

UniProt: O14744

Pathways: Chromatin Binding, Regulation of Muscle Cell Differentiation, Ribonucleoprotein Complex Subunit Organization, Skeletal Muscle Fiber Development