Cyclin D1 anticorps (Middle Region)

N° du produit ABIN2779291

L’anticorps anti-Cyclin D1 Polyclonal Lapin est utilisé pour la détection de Cyclin D1 dans des échantillons de Humain, Rat, Boeuf (Vache), Chien, Poisson zèbre (Danio rerio), Cheval, Lapin, Porc et Saccharomyces cerevisiae. Il a été validé pour WB.

Aperçu rapide pour Cyclin D1 anticorps (Middle Region) (ABIN2779291)

Antigène: Cyclin D1 (CCND1)

Reactivité: Humain, Rat, Boeuf (Vache), Chien, Poisson zèbre (Danio rerio), Cheval, Lapin, Porc, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin D1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Cyclin D1 anticorps

Épitope: Middle Region

Fonction: CCND1 Antibody - middle region

Séquence: ACQEQIEALL ESSLRQAQQN MDPKAAEEEE EEEEEVDLAC TPTDVRDVDI

Homologie: Cow: 92%, Dog: 92%, Horse: 92%, Human: 100%, Pig: 91%, Rabbit: 83%, Rat: 85%, Yeast: 83%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against CCND1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CCND1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP30163-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Cyclin D1

Antigène: Cyclin D1 (CCND1)

Autre désignation: CCND1

Sujet:

Background Information: CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Cyclin D1

Alternative Symbols: BCL1, PRAD1, U21B31, D11S287E

Protein Name: G1/S-specific cyclin-D1

Poids moléculaire: 34kDa

ID gène: 595

NCBI Accession: NP_444284

UniProt: P24385

Pathways: Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, ER-Nucleus Signaling