TLE1 anticorps (N-Term)

N° du produit ABIN2779588

Détail du produit anti-TLE1 anticorps

Antigène: TLE1 (Transducin-Like Enhancer of Split 1 (E(sp1) Homolog, Drosophila) (TLE1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Boeuf (Vache), Chien, Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLE1 est non-conjugé

Application: Western Blotting (WB)

Séquence: RNGPEFSNDI KKRKVDDKDS SHYDSDGDKS DDNLVVDVSN EDPSSPRASP

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against TLE1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human TLE1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 770 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur TLE1

Antigène: TLE1 (Transducin-Like Enhancer of Split 1 (E(sp1) Homolog, Drosophila) (TLE1))

Autre désignation: TLE1 (TLE1 Produits)

Synonymes: anticorps ESG, anticorps ESG1, anticorps GRG1, anticorps C230057C06Rik, anticorps Estm14, anticorps Grg1, anticorps Tle4l, anticorps TLE1, anticorps transducin like enhancer of split 1, anticorps transducin-like enhancer protein 1, anticorps transducin-like enhancer of split 1, anticorps transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila), anticorps TLE1, anticorps Smp_150080, anticorps Tle1, anticorps LOC100354911, anticorps LOC100524475, anticorps LOC100061341

Sujet: TLE1 is a transcriptional corepressor that binds to a number of transcription factors. TLE1 inhibits NF-kappa-B-regulated gene expression and the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. TLE1 has an unusual function as coactivator for ESRRG.
Alias Symbols: ESG, ESG1, GRG1
Protein Interaction Partner: TLE1, TCF3, TCF4, UBC, SS18, SSX2, HDAC1, EZH2, ATF2, APH1A, LEF1, TLX3, PROP1, HES1, TLX1, HHEX, FOXG1, ESRRG, EN1, tcf7l1a, NOD2, AES, HESX1, GSK3B, GRB7, NUDT21, DAZAP2, KIAA0408, TSC22D1, TK1, SMN1, RAP1B, GADD45A, CSNK2B, RCC1, CDKN1A, BID, BCL2L1, A
Protein Size: 770

Poids moléculaire: 83 kDa

ID gène: 7088

NCBI Accession: NM_005077, NP_005068

UniProt: Q04724

Pathways: Signalisation WNT, SARS-CoV-2 Protein Interactome