SIRT1 anticorps (N-Term)

N° du produit ABIN2779607

Cet anticorps Lapin Polyclonal détecte spécifiquement SIRT1 dans WB. Il présente une réactivité envers Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye, Cheval et Poisson zèbre (Danio rerio) et a été mentionné dans 5+ publications.

Aperçu rapide pour SIRT1 anticorps (N-Term) (ABIN2779607)

Antigène: SIRT1 (Sirtuin 1 (SIRT1))

Reactivité: Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye, Cheval, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIRT1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SIRT1 anticorps

Épitope: N-Term

Séquence: PETIPPPELD DMTLWQIVIN ILSEPPKRKK RKDINTIEDA VKLLQECKKI

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Attributs du produit: This is a rabbit polyclonal antibody against SIRT1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SIRT1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 747 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SIRT1 (ABIN2779607)

Takumida, Takumida, Katagiri, Anniko: "Localization of sirtuins (SIRT1-7) in the aged mouse inner ear." dans: Acta oto-laryngologica, pp. 1-12, (2015) (PubMed).

Cueno, Imai, Tamura, Ochiai: "Butyric acid-induced rat jugular blood cytosolic oxidative stress is associated with SIRT1 decrease." dans: Cell stress & chaperones, Vol. 19, Issue 2, pp. 295-8, (2014) (PubMed).

Hsu, Chuang: "Changes in energy-regulated molecules in the trophocytes and fat cells of young and old worker honeybees (Apis mellifera)." dans: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 69, Issue 8, pp. 955-64, (2014) (PubMed).

Hsu, Hu: "Energy-regulated molecules maintain young status in the trophocytes and fat cells of old queen honeybees." dans: Biogerontology, Vol. 15, Issue 4, pp. 389-400, (2014) (PubMed).

Anavekar, Mirza, Skali, Plappert, St John Sutton, Pfeffer, Solomon,: "Risk assessment in patients with depressed left ventricular function after myocardial infarction using the myocardial performance index--Survival and Ventricular Enlargement (SAVE) experience." dans: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Vol. 19, Issue 1, pp. 28-33, (2006) (PubMed).

Détails sur SIRT1

Antigène: SIRT1 (Sirtuin 1 (SIRT1))

Autre désignation: SIRT1

Sujet: SIRT1 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined,
Alias Symbols: SIR2L1
Protein Interaction Partner: SIRT2, KAT5, IRS1, ING2, ING1, HSP90AA1, AR, EP300, CDK1, CCNB1, RPS19BP1, KAT8, CLOCK, IRS2, UBE2I, TP53, STK11, WRN, PPARGC1A, FOXO1, VHL, UBC, E2F1, PSME3, KCNA5, KCNA4, KCNAB2, POP1, PPARA, CAP1, KIAA1598, TPM4, FASN, CDKL1, HIC1, HDAC4, CHD3, CDK6, S
Protein Size: 747

Poids moléculaire: 82 kDa

ID gène: 23411

NCBI Accession: NM_012238, NP_036370

UniProt: Q96EB6

Pathways: Signalisation MAPK, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Negative Regulation of intrinsic apoptotic Signaling