NCOR2 anticorps (N-Term)

N° du produit ABIN2779658

Détail du produit anti-NCOR2 anticorps

Antigène: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache), Chien, Poisson zèbre (Danio rerio), Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NCOR2 est non-conjugé

Application: Western Blotting (WB)

Séquence: PMPRSSQEEK DEKEKEKEAE KEEEKPEVEN DKEDLLKEKT DDTSGEDNDE

Homologie: Cow: 93%, Dog: 86%, Human: 100%, Mouse: 86%, Pig: 100%, Rat: 86%, Yeast: 87%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against NCOR2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human NCOR2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 2524 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur NCOR2

Antigène: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Autre désignation: NCOR2 (NCOR2 Produits)

Synonymes: anticorps CTG26, anticorps N-CoR2, anticorps SMAP270, anticorps SMRT, anticorps SMRTE, anticorps SMRTE-tau, anticorps TNRC14, anticorps TRAC, anticorps TRAC-1, anticorps TRAC1, anticorps N-CoR, anticorps SMRTe, anticorps NCOR2, anticorps gb:be017685, anticorps si:bz71m17.2, anticorps smrt, anticorps ctg26, anticorps smrte, anticorps trac1, anticorps tnrc14, anticorps trac-1, anticorps smrte-tau, anticorps nuclear receptor corepressor 2, anticorps nuclear receptor co-repressor 2, anticorps NCOR2, anticorps Ncor2, anticorps ncor2

Sujet: NCOR2 forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. NCOR2 mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.
Alias Symbols: SMRT, TRAC, CTG26, SMRTE, TRAC1, N-CoR2, TNRC14, TRAC-1, SMAP270, SMRTE-tau
Protein Interaction Partner: HDAC4, HDAC3, RARA, HMGA1, HDAC2, HDAC1, AURKA, BCL6, BCOR, GPS2, ZBTB16, UBC, E2F1, NR1I2, BTRC, HDAC7, NR1H2, THRA, RUNX1, Pparg, Nr2f1, Nr1i3, Nr2f2, CBX6, C1D, NR1H4, NR1D1, Ppard, SUMO2, CTBP1, ARNT, AHR, NCOR1, AR, NRD1, E2F4, ZBTB7A, SOX2, ESR1, CE
Protein Size: 2524

Poids moléculaire: 275 kDa

ID gène: 9612

NCBI Accession: NM_006312, NP_006303

UniProt: Q9Y618

Pathways: Signalisation Notch, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha