NCOR2 anticorps (N-Term)

N° du produit ABIN2779658

Cet anticorps anti-NCOR2 Polyclonal Lapin (ABIN2779658) détecte spécifiquement NCOR2 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Porc, Boeuf (Vache), Chien, Poisson zèbre (Danio rerio) et Saccharomyces cerevisiae.

Aperçu rapide pour NCOR2 anticorps (N-Term) (ABIN2779658)

Antigène: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache), Chien, Poisson zèbre (Danio rerio), Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NCOR2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-NCOR2 anticorps

Épitope: N-Term

Fonction: NCOR2 Antibody - N-terminal region

Séquence: PMPRSSQEEK DEKEKEKEAE KEEEKPEVEN DKEDLLKEKT DDTSGEDNDE

Homologie: Cow: 93%, Dog: 86%, Human: 100%, Mouse: 86%, Pig: 100%, Rat: 86%, Yeast: 87%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against NCOR2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human NCOR2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8106764

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur NCOR2

Antigène: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Autre désignation: NCOR2

Sujet:

Background Information: NCOR2 forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. NCOR2 mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.

Gene Name: Nuclear receptor corepressor 2

Alternative Symbols: SMRT, TRAC, CTG26, SMRTE, TRAC1, N-CoR2, TNRC14, TRAC-1, SMAP270, SMRTE-tau

Protein Name: Nuclear receptor corepressor 2

Poids moléculaire: 275kDa

ID gène: 9612

NCBI Accession: NP_006303

UniProt: Q9Y618

Pathways: Signalisation Notch, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha