DNMT1 anticorps (N-Term)
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- Antigène Voir toutes DNMT1 Anticorps
- DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))
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Épitope
- N-Term
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Reactivité
- Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DNMT1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- SSVATRRTTR QTTITAHFTK GPTKRKPKEE SEEGNSAESA AEERDQDKKR
- Homologie
- Mouse: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against Dnmt1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of mouse Dnmt1
- Top Product
- Discover our top product DNMT1 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Antigen size: 1619 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))
- Autre désignation
- Dnmt1 (DNMT1 Produits)
- Synonymes
- anticorps cb1075, anticorps cb983, anticorps dmnt1, anticorps fb05h01, anticorps mta, anticorps wu:fb05h01, anticorps ADCADN, anticorps AIM, anticorps CXXC9, anticorps DNMT, anticorps HSN1E, anticorps MCMT, anticorps DDM2, anticorps DECREASED DNA METHYLATION 2, anticorps DMT01, anticorps DMT1, anticorps DNA METHYLTRANSFERASE, anticorps DNA METHYLTRANSFERASE 01, anticorps DNA METHYLTRANSFERASE 1, anticorps MET2, anticorps METHYLTRANSFERASE 2, anticorps METHYLTRANSFERASE I, anticorps METI, anticorps methyltransferase 1, anticorps Cxxc9, anticorps Dnmt, anticorps Dnmt1o, anticorps MTase, anticorps Met-1, anticorps Met1, anticorps MommeD2, anticorps m.MmuI, anticorps DNA methyltransferase 1, anticorps DNA (cytosine-5-)-methyltransferase 1, anticorps methyltransferase 1, anticorps DNA methyltransferase (cytosine-5) 1, anticorps DNMT1, anticorps dnmt1, anticorps Dnmt1, anticorps MET1
- Sujet
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Dnmt1 methylates CpG residues.Dnmt1 preferentially methylates hemimethylated DNA. Dnmt1 associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance.Dnmt1 associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones.Dnmt1 mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, Dnmt1 is involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
Alias Symbols: Cxxc9, Dnmt, Dnmt1o, MTase, Met-1, Met1, MommeD2, MCMT, m.MmuI
Protein Interaction Partner: Uhrf1, Parp1, Eed, hist1h3g, DSK2, VPS9, Kat5, Ubc, Atm, NUB1, UBQLN1, SQSTM1, PSMD4, NBR1, RAD23B, Hesx1, Ezh2, Zbtb16, Cul3, Cdh1, Dmap1, Tcf3, hist1h4a, hist1h2bj, hist2h2ab, Dnmt1, Kcnq1ot1, Pla2g2a, Apc, Tox3, Rela, HDAC1,
Protein Size: 1619 - Poids moléculaire
- 183 kDa
- ID gène
- 13433
- NCBI Accession
- NM_010066, NP_034196
- UniProt
- P13864
- Pathways
- SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2
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