TANK anticorps (N-Term)

N° du produit ABIN2780571

Cet anticorps Lapin Polyclonal détecte spécifiquement TANK dans WB et IHC. Il présente une réactivité avec des échantillons de Humain, Rat, Souris, Lapin, Boeuf (Vache), Cheval, Chien, Cobaye et Porc.

Aperçu rapide pour TANK anticorps (N-Term) (ABIN2780571)

Antigène: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Reactivité: Humain, Rat, Souris, Lapin, Boeuf (Vache), Cheval, Chien, Cobaye, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TANK est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-TANK anticorps

Épitope: N-Term

Fonction: TANK Antibody - N-terminal region

Séquence: DKNIGEQLNK AYEAFRQACM DRDSAVKELQ QKTENYEQRI REQQEQLSLQ

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 86%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against TANK. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human TANK

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP38421-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur TANK

Antigène: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Autre désignation: TANK

Sujet:

Background Information: The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. TANK is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, TANK can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation.The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: TRAF family member-associated NFKB activator

Alternative Symbols: ITRAF, TRAF2, I-TRAF

Protein Name: TRAF family member-associated NF-kappa-B activator

Poids moléculaire: 48kDa

ID gène: 10010

NCBI Accession: NP_004171

UniProt: Q92844

Pathways: Signalisation p53, Signalisation TLR, Activation of Innate immune Response