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RUNX2 anticorps (C-Term)

RUNX2 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio), Porc, Lapin WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2780589
  • Antigène Voir toutes RUNX2 Anticorps
    RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))
    Épitope
    • 23
    • 16
    • 9
    • 7
    • 7
    • 7
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 142
    • 70
    • 43
    • 9
    • 8
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio), Porc, Lapin
    Hôte
    • 131
    • 14
    Lapin
    Clonalité
    • 123
    • 22
    Polyclonal
    Conjugué
    • 64
    • 11
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Cet anticorp RUNX2 est non-conjugé
    Application
    • 96
    • 49
    • 31
    • 26
    • 13
    • 11
    • 9
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    TTTSNGSTLL NPNLPNQNDG VDADGSHSSS PTVLNSSGRM DESVWRPY
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 83%, Rat: 100%, Zebrafish: 92%
    Attributs du produit
    This is a rabbit polyclonal antibody against RUNX2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the C terminal region of human RUNX2
    Top Product
    Discover our top product RUNX2 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 507 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Wang, He, Liu, Liu, Zhou, Hao, Sun, Wang: "Synergistic effects of overexpression of BMP‑2 and TGF‑β3 on osteogenic differentiation of bone marrow mesenchymal stem cells." dans: Molecular medicine reports, Vol. 14, Issue 6, pp. 5514-5520, (2016) (PubMed).

  • Antigène
    RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))
    Autre désignation
    RUNX2 (RUNX2 Produits)
    Synonymes
    anticorps AML3, anticorps CBF-alpha-1, anticorps CBFA1, anticorps CCD, anticorps CCD1, anticorps CLCD, anticorps OSF-2, anticorps OSF2, anticorps PEA2aA, anticorps PEBP2aA, anticorps Cbf, anticorps Cbfa-1, anticorps Cbfa1, anticorps LS3, anticorps Osf2, anticorps Pebp2a1, anticorps Pebpa2a, anticorps runx2, anticorps RUNX2, anticorps ccd, anticorps aml3, anticorps ccd1, anticorps osf2, anticorps cbfa1, anticorps pea2aa, anticorps pebp2a1, anticorps pebp2a2, anticorps pebp2aa, anticorps pebp2aa1, anticorps runt related transcription factor 2, anticorps runt-related transcription factor 2a, anticorps runt-related transcription factor 2, anticorps runt related transcription factor 2 L homeolog, anticorps RUNX2, anticorps runx2a, anticorps Runx2, anticorps runx2, anticorps LOC703331, anticorps LOC100549663, anticorps runx2.L
    Sujet
    RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis, acting as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants, encoding different protein isoforms, result from alternate promoter use as well as alternate splicing.This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.
    Alias Symbols: AML3, CBFA1, CCD, CCD1, MGC120022, MGC120023, OSF2, PEA2aA, PEBP2A1, PEBP2A2, PEBP2aA, PEBP2aA1, OSF-2
    Protein Interaction Partner: HDAC7, HDAC6, TP53, UBC, RB1, PML, HIF1A, SMURF1, SMAD1, SMURF2, HIVEP3, WWP1, FHL2, UBTF, SUV39H1, HDAC1, STAT3, SMAD3, RBM14, SOX9, NR0B2, EP300, HDAC5, HDAC4, HDAC3, CREBBP, XRCC5, HES1, XRCC6, BMPR1A, KAT2B, TLE1, YAP1, KAT6B, TAF1A, AXIN1, SMAD6, MAP
    Protein Size: 507
    Poids moléculaire
    55 kDa
    ID gène
    860
    NCBI Accession
    NM_004348, NP_004339
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