RELB anticorps (Middle Region)

N° du produit ABIN2780785

Cet anticorps Lapin Polyclonal détecte spécifiquement RELB dans WB. Il présente une réactivité envers Humain, Chien, Boeuf (Vache), Cheval et Porc.

Aperçu rapide pour RELB anticorps (Middle Region) (ABIN2780785)

Antigène: RELB (V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB))

Reactivité: Humain, Chien, Boeuf (Vache), Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RELB est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RELB anticorps

Épitope: Middle Region

Séquence: DLLPPAPPHA SAVVCSGGAG AVVGETPGPE PLTLDSYQAP GPGDGGTASL

Homologie: Cow: 100%, Dog: 100%, Horse: 93%, Human: 100%, Pig: 86%

Attributs du produit: This is a rabbit polyclonal antibody against RELB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human RELB

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 579 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RELB

Antigène: RELB (V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB))

Autre désignation: RELB

Sujet: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49.
Alias Symbols: I-REL, IREL, REL-B
Protein Interaction Partner: NFKB2, NFKB1, BCL3, NEK6, DNMT1, DAXX, MT1M, GSK3B, CTSL, CDK1, BUD31, UQCRFS1, MTAP, COMMD9, COMMD5, MALT1, COMMD1, COMMD8, COMMD4, COMMD10, COMMD2, UBC, RAC1, SUZ12, RELA, EZH2, DPF2, YY1, CBX3, EHMT2, NFKBIA, KPNA6, SMARCA4, SMARCE1, SMARCC2, SMARCC1,
Protein Size: 579

Poids moléculaire: 62 kDa

ID gène: 5971

NCBI Accession: NM_006509, NP_006500

UniProt: Q01201

Pathways: Signalisation NF-kappaB, Signalisation RTK