Growth Hormone Receptor anticorps (N-Term)
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- Antigène Voir toutes Growth Hormone Receptor (GHR) Anticorps
- Growth Hormone Receptor (GHR)
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Épitope
- N-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Growth Hormone Receptor est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- LQSVNPGLKT NSSKEPKFTK CRSPERETFS CHWTDEVHHG TKNLGPIQLF
- Homologie
- Human: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against GHR. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human GHR
- Top Product
- Discover our top product GHR Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 638 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- Growth Hormone Receptor (GHR)
- Autre désignation
- GHR (GHR Produits)
- Synonymes
- anticorps GHBP, anticorps AA986417, anticorps GHR/BP, anticorps GHR, anticorps ghr, anticorps ghr.a, anticorps zgc:162141, anticorps growth hormone receptor, anticorps growth hormone receptor L homeolog, anticorps growth hormone receptor a, anticorps GHR, anticorps Ghr, anticorps ghr.L, anticorps ghr, anticorps ghra
- Sujet
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GHR is a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature.This gene encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: GHBP
Protein Interaction Partner: FBXW11, JAK2, GHR, GH1, BTRC, UBC, SKP1, SOCS2, STUB1, PTPRH, PTPRB, PTPN13, PTPN9, PTPN3, PTPN2, PTPN1, DUSP7, NCOA6, STAT5B, SOCS3, SOCS1, SGTA, CISH, GRB10, STAT5A, AP2A1, SHC1, TYK2, PTPN6, PTPN11, PRLR, PIK3R1, JAK1, IRS1, GH2, GRB2, STAT3, PLCG1,
Protein Size: 638 - Poids moléculaire
- 70 kDa
- ID gène
- 2690
- NCBI Accession
- NM_000163, NP_000154
- UniProt
- P10912
- Pathways
- Signalisation NF-kappaB, Signalistation JAK/STAT, Response to Growth Hormone Stimulus
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