Growth Hormone Receptor anticorps (C-Term)

N° du produit ABIN2781773

L’anticorps Lapin Polyclonal anti-Growth Hormone Receptor a été validé pour WB. Il convient pour détecter Growth Hormone Receptor dans des échantillons de Humain, Porc, Cheval et Chien.

Aperçu rapide pour Growth Hormone Receptor anticorps (C-Term) (ABIN2781773)

Antigène: Growth Hormone Receptor (GHR)

Reactivité: Humain, Porc, Cheval, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Growth Hormone Receptor est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Growth Hormone Receptor anticorps

Épitope: C-Term

Séquence: YSLKVDKEYE VRVRSKQRNS GNYGEFSEVL YVTLPQMSQF TCEEDFYFPW

Homologie: Dog: 79%, Horse: 79%, Human: 100%, Pig: 79%

Attributs du produit: This is a rabbit polyclonal antibody against GHR. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human GHR

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Growth Hormone Receptor

Antigène: Growth Hormone Receptor (GHR)

Autre désignation: GHR

Sujet: This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein.
Alias Symbols: GHBP
Protein Interaction Partner: FBXW11, JAK2, GHR, GH1, BTRC, UBC, SKP1, SOCS2, STUB1, PTPRH, PTPRB, PTPN13, PTPN9, PTPN3, PTPN2, PTPN1, DUSP7, NCOA6, STAT5B, SOCS3, SOCS1, SGTA, CISH, GRB10, STAT5A, AP2A1, SHC1, TYK2, PTPN6, PTPN11, PRLR, PIK3R1, JAK1, IRS1, GH2, GRB2, STAT3, PLCG1,
Protein Size: 294

Poids moléculaire: 32 kDa

ID gène: 2690

NCBI Accession: NM_001242462, NP_001229391

Pathways: Signalisation NF-kappaB, Signalistation JAK/STAT, Response to Growth Hormone Stimulus