LDLR anticorps (C-Term)

N° du produit ABIN2781810

Cet anticorps Lapin Polyclonal détecte spécifiquement LDLR dans WB. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Porc, Lapin et Cheval.

Aperçu rapide pour LDLR anticorps (C-Term) (ABIN2781810)

Antigène: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Porc, Lapin, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LDLR est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-LDLR anticorps

Épitope: C-Term

Séquence: VDSKLHSISS IDVNGGNRKT ILEDEKRLAH PFSLAVFEDK VFWTDIINEA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against LDLR. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human LDLR

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur LDLR

Antigène: LDLR (Low Density Lipoprotein Receptor (LDLR))

Autre désignation: LDLR

Sujet: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
Alias Symbols: FH, FHC, LDLCQ2
Protein Interaction Partner: PCSK9, UBC, env, MAP4, PDIA3, CREBBP, PDIA4, HSP90B1, HSPA5, CANX, MYLIP, AP1M2, LDLR, SNX17, LDLRAP1, DAB1, PF4, APOE, APOB, LRPAP1, DAB2, CD36,
Protein Size: 682

Poids moléculaire: 75 kDa

ID gène: 3949

NCBI Accession: NM_001195803, NP_001182732

Pathways: Hepatitis C, Lipid Metabolism