CBS anticorps (N-Term)

N° du produit ABIN2782348

Détail du produit anti-CBS anticorps

Antigène: CBS (Cystathionine-beta-Synthase (CBS))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin, Saccharomyces cerevisiae, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBS est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: RCIIVMPEKM SSEKVDVLRA LGAEIVRTPT NARFDSPESH VGVAWRLKNE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 86%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against CBS. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CBS

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 551 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-CBS (ABIN2782348)

Yamane, Kanno, Nakamura, Fujino, Murayama: "Hydrogen sulfide-mediated regulation of contractility in the mouse ileum with electrical stimulation: roles of L-cysteine, cystathionine β-synthase, and K+ channels." dans: European journal of pharmacology, Vol. 740, pp. 112-20, (2014) (PubMed).

Geillinger, Rathmann, Köhrle, Fiamoncini, Daniel, Kipp: "Hepatic metabolite profiles in mice with a suboptimal selenium status." dans: The Journal of nutritional biochemistry, Vol. 25, Issue 9, pp. 914-22, (2014) (PubMed).

Porteus, Abdallah, Pollack, Kumai, Kwong, Yew, Milsom, Perry: "The role of hydrogen sulphide in the control of breathing in hypoxic zebrafish (Danio rerio)." dans: The Journal of physiology, Vol. 592, Issue 14, pp. 3075-88, (2014) (PubMed).

Dahlhoff, Worsch, Sailer, Hummel, Fiamoncini, Uebel, Obeid, Scherling, Geisel, Bader, Daniel: "Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels." dans: Molecular metabolism, Vol. 3, Issue 5, pp. 565-80, (2014) (PubMed).

Fernandes, Ribeiro, Martínez, Orensanz, Barahona, Martínez-Sáenz, Recio, Benedito, Bustamante, Carballido, García-Sacristán, Prieto, Hernández: "Endogenous hydrogen sulfide has a powerful role in inhibitory neurotransmission to the pig bladder neck." dans: The Journal of urology, Vol. 189, Issue 4, pp. 1567-73, (2013) (PubMed).

Markand, Tawfik, Ha, Gnana-Prakasam, Sonne, Ganapathy, Sen, Xian, Smith: "Cystathionine beta synthase expression in mouse retina." dans: Current eye research, Vol. 38, Issue 5, pp. 597-604, (2013) (PubMed).

Dahlhoff, Desmarchelier, Sailer, Fürst, Haag, Ulbrich, Hummel, Obeid, Geisel, Bader, Daniel: "Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism." dans: PLoS ONE, Vol. 8, Issue 3, pp. e57387, (2013) (PubMed).

Spellman, Ahmed, Dubach, Gardiner: "Expression of trisomic proteins in Down syndrome model systems." dans: Gene, Vol. 512, Issue 2, pp. 219-25, (2012) (PubMed).

Détails sur CBS

Antigène: CBS (Cystathionine-beta-Synthase (CBS))

Autre désignation: CBS (CBS Produits)

Synonymes: anticorps hip4, anticorps GB12529, anticorps CBS, anticorps DDBDRAFT_0189727, anticorps DDBDRAFT_0191292, anticorps DDB_0189727, anticorps DDB_0191292, anticorps cbs, anticorps AI047524, anticorps AI303044, anticorps HIP4, anticorps cb442, anticorps wu:fb37g05, anticorps wu:fm61c07, anticorps wu:fq06c06, anticorps zgc:113704, anticorps cystathionine-beta-synthase L homeolog, anticorps cystathionine-beta-synthase, anticorps cystathionine beta-synthase, anticorps cystathionine beta-synthase CBS, anticorps cystathionine beta synthase, anticorps cystathionine-beta-synthase S homeolog, anticorps cystathionine-beta-synthase b, anticorps cbs.L, anticorps cbs, anticorps Cbs, anticorps CBS, anticorps CNA06170, anticorps Tb11.02.5400, anticorps cysB, anticorps LOC100635325, anticorps cbs.S, anticorps cbsb

Sujet: CBS is involved in the transsulfuration pathway. The first step of this pathway, from homocysteine to cystathionine, is catalyzed by this protein. CBS deficiency can cause homocystinuria which affects many organs and tissues, including the eyes and the skeletal, vascular and central nervous systems.The protein encoded by this gene is involved in the transsulfuration pathway. The first step of this pathway, from homocysteine to cystathionine, is catalyzed by this protein. CBS deficiency can cause homocystinuria which affects many organs and tissues, including the eyes and the skeletal, vascular and central nervous systems.
Alias Symbols: HIP4
Protein Interaction Partner: UBASH3A, UBE2I, PSMA1, PRKAG1, PIN1, EHHADH, CBS, SUMO1, UBC, NEDD8, PIAS3, RANBP9, PIAS1, CBX4, SRP14, RAD23B, PKM, NUCB1, IREB2, HSF1, LRSAM1, C14orf142, UBA5, IPO4, GOPC, PARP6, NPLOC4, DERA, ERO1L, DBNL, GPN1, PDLIM5, PLIN3, UBA2, GPSM1, COL4A3BP, UGP
Protein Size: 551

Poids moléculaire: 60 kDa

ID gène: 875

NCBI Accession: NM_000071, NP_000062

UniProt: P35520