MRPS12 anticorps (N-Term)

N° du produit ABIN2782575

Cet anticorps anti-MRPS12 Polyclonal Lapin (ABIN2782575) détecte spécifiquement MRPS12 dans WB. L’anticorps est réactif avec des échantillons de Humain, Rat, Boeuf (Vache), Chien, Cobaye et Cheval.

Aperçu rapide pour MRPS12 anticorps (N-Term) (ABIN2782575)

Antigène: MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))

Reactivité: Humain, Rat, Boeuf (Vache), Chien, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MRPS12 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MRPS12 anticorps

Épitope: N-Term

Fonction: MRPS12 Antibody - N-terminal region

Séquence: LVPRLWATCS MATLNQMHRL GPPKRPPRKL GPTEGRPQLK GVVLCTFTRK

Homologie: Cow: 86%, Dog: 91%, Guinea Pig: 86%, Horse: 79%, Human: 100%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against MRPS12. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human MRPS12

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46301-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur MRPS12

Antigène: MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))

Autre désignation: MRPS12

Sujet:

Background Information: Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. MRPS12 is the 28S subunit protein that belongs to the ribosomal protein S12P family. The protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics.Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75 % protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene, all three variants encode the same protein.

Gene Name: Mitochondrial ribosomal protein S12

Alternative Symbols: RPS12, RPMS12, RPSM12, MPR-S12, MT-RPS12

Protein Name: 28S ribosomal protein S12, mitochondrial

Poids moléculaire: 12kDa

ID gène: 6183

NCBI Accession: NP_066930

UniProt: O15235

Pathways: Sensory Perception of Sound