RMI1 anticorps (N-Term)

N° du produit ABIN2782588

Détail du produit anti-RMI1 anticorps

Antigène: RMI1 (Homolog of Yeast RecQ-mediated Genome Instability 1 (RMI1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Cheval, Boeuf (Vache), Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RMI1 est non-conjugé

Application: Western Blotting (WB)

Séquence: DGILEIPKGE LNGFYALQIN SLVDVSQPAY SQIQKLRGKN TTNDLVTAEA

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against RMI1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human RMI1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 625 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RMI1

Antigène: RMI1 (Homolog of Yeast RecQ-mediated Genome Instability 1 (RMI1))

Autre désignation: RMI1 (RMI1 Produits)

Synonymes: anticorps BLAP75, anticorps C9orf76, anticorps FAAP75, anticorps RP11-346I8.1, anticorps RGD1310671, anticorps 4932432N11Rik, anticorps C79893, anticorps MGC55882, anticorps zgc:55882, anticorps RecQ mediated genome instability 1, anticorps RecQ mediated genome instability 1 L homeolog, anticorps RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae), anticorps RMI1, anticorps Rmi1, anticorps rmi1.L, anticorps rmi1

Sujet: RMI1 is an essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. RMI1 promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. RMI1 is required for BLM phosphorylation during mitosis. Within the BLM complex, RMI1 is required for BLM and TOP3A stability.RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions (Raynard et al., 2006 [PubMed 16595695]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-136 BP327553.1 1-136 137-885 DN997105.1 9-757 886-2740 AL732446.4 14777-16631 2741-3508 BC039999.2 2566-3333
Alias Symbols: BLAP75, C9orf76, FLJ12888, RP11-346I8.1
Protein Interaction Partner: APITD1, STRA13, UBC, RPA3, RPA2, RPA1, TOPBP1, BLM, NR1H2, UBE3A, HSPA13, PFDN1, Ercc6l, Top3a, FANCM, RMI2, FANCF, RMI1, FANCA,
Protein Size: 625

Poids moléculaire: 70 kDa

ID gène: 80010

NCBI Accession: NM_024945, NP_079221

UniProt: Q9H9A7

Pathways: Réparation de l'ADN