HYOU1 anticorps (Middle Region)

N° du produit ABIN2782712

Il existe 1 publication pour ce produit. L’anticorps anti-HYOU1 Polyclonal Lapin est utilisé pour la détection de HYOU1 dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval et Lapin. Il a été validé pour WB.

Aperçu rapide pour HYOU1 anticorps (Middle Region) (ABIN2782712)

Antigène: HYOU1 (Hypoxia Up Regulated 1 (HYOU1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HYOU1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-HYOU1 anticorps

Épitope: Middle Region

Fonction: HYOU1 Antibody - middle region

Séquence: DREVQYLLNK AKFTKPRPRP KDKNGTRAEP PLNASASDQG EKVIPPAGQT

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against HYOU1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human HYOU1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46716-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-HYOU1 (ABIN2782712)

Du, Rong, Hui, Peng, Jin, Li, Wang, Li: "Expression and function of HSP110 family in mouse testis after vasectomy." dans: Asian journal of andrology, Vol. 19, Issue 3, pp. 355-361, (2016) (PubMed).

Détails sur HYOU1

Antigène: HYOU1 (Hypoxia Up Regulated 1 (HYOU1))

Autre désignation: HYOU1

Sujet:

Background Information: The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal.

Gene Name: Hypoxia up-regulated 1

Alternative Symbols: IMD59, Grp170, HSP12A, ORP150, GRP-170, ORP-150

Protein Name: Hypoxia up-regulated protein 1

Poids moléculaire: 108kDa

ID gène: 10525

NCBI Accession: NP_006380

UniProt: Q9Y4L1

Pathways: ER-Nucleus Signaling, SARS-CoV-2 Protein Interactome