Transglutaminase 2 anticorps (Middle Region)

N° du produit ABIN2782978

L’anticorps Lapin Polyclonal anti-Transglutaminase 2 a été validé pour WB et IHC. Il convient pour détecter Transglutaminase 2 dans des échantillons de Humain, Souris, Rat, Lapin, Cobaye, Boeuf (Vache), Chien, Cheval et Poisson zèbre (Danio rerio).

Aperçu rapide pour Transglutaminase 2 anticorps (Middle Region) (ABIN2782978)

Antigène: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Reactivité: Humain, Souris, Rat, Lapin, Cobaye, Boeuf (Vache), Chien, Cheval, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Transglutaminase 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Transglutaminase 2 anticorps

Épitope: Middle Region

Séquence: VGRDEREDIT HTYKYPEGSS EEREAFTRAN HLNKLAEKEE TGMAMRIRVG

Homologie: Cow: 91%, Dog: 91%, Guinea Pig: 93%, Horse: 91%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 91%

Attributs du produit: This is a rabbit polyclonal antibody against TGM2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human TGM2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 548 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Transglutaminase 2

Antigène: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Autre désignation: TGM2

Sujet: Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. TGM2 acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, TGM2 is the autoantigen implicated in celiac disease.Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: TG2, TGC, GNAH, G-ALPHA-h
Protein Interaction Partner: UBC, SUMO1, NEDD8, YWHAG, UBE2V1, RPS6KA3, PGD, PAK2, LDHB, G6PD, ECHS1, CSE1L, CKB, ZFYVE19, TXNDC5, SMEK2, UBFD1, CNDP2, YWHAQ, NPEPPS, SLC9A3R1, YWHAZ, FBXO6, ADAR, ABCA1, A2M, VHL, TGM2, SMAD3, SMAD2, HSPA8, HSPA1B, HSPA1A, HP, HNRNPF, GRN, GCGR, FNTA
Protein Size: 548

Poids moléculaire: 62 kDa

ID gène: 7052

NCBI Accession: NM_198951, NP_945189

Pathways: Tube Formation, Thromboxane A2 Receptor Signaling