SETD7 anticorps (C-Term)

N° du produit ABIN2783571

Cet anticorps Lapin Polyclonal détecte spécifiquement SETD7 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Chien, Cheval, Porc, Lapin, Boeuf (Vache), Poisson zèbre (Danio rerio) et Cobaye.Il a été cité dans 1 publication.

Aperçu rapide pour SETD7 anticorps (C-Term) (ABIN2783571)

Antigène: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Reactivité: Humain, Souris, Rat, Chien, Cheval, Porc, Lapin, Boeuf (Vache), Poisson zèbre (Danio rerio), Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SETD7 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SETD7 anticorps

Épitope: C-Term

Séquence: PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP EWYQVELKAF

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against SETD7. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human SETD7

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 366 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SETD7 (ABIN2783571)

Subramanian, Jia, Kapoor-Vazirani, Powell, Collins, Sharma, Peng, Cheng, Vertino: "Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase." dans: Molecular cell, Vol. 30, Issue 3, pp. 336-47, (2008) (PubMed).

Détails sur SETD7

Antigène: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Autre désignation: SETD7

Sujet: SETD7 is a histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. It is recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. It has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins.
Alias Symbols: FLJ21193, KIAA1717, KMT7, SET7, SET7/9, SET9
Protein Interaction Partner: KLF4, HIST3H3, SOX2, PRKAR1A, A1BG, TP53, NR2F2, STEAP3, SERTAD1, DPY30, MED1, MYOD1, E2F1, HIST1H3A, SMARCA4, H3F3A, STAT3, RELA, AR, UBC, DNMT1, PPP1R12A, SIRT1, TBP, TAF10, TAF7, TAF6, HIST1H4A, ESR1, HIST2H3C, HCFC1, L3MBTL1,
Protein Size: 366

Poids moléculaire: 41 kDa

ID gène: 80854

NCBI Accession: NM_030648, NP_085151

UniProt: Q8WTS6